Evaluation of flow biosensor technology in a chronically-instrumented non-human primate model

The Physiology Research Branch at Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on the cardiovascular system and to identify the particular mechanisms that invoke these responses. Primary investigative research efforts in a...

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Published in1995 IEEE Engineering in Medicine and Biology : 17th annual conference and 21st Canadian Medical and Biological Engineering Conference : Montréal, Canada, September 20-23, 1995 Vol. 2; pp. 1573 - 1574 vol.2
Main Authors Koenig, S.C., Reister, C., Schaub, J., Muniz, G., Ferguson, T., Fanton, J.W.
Format Conference Proceeding
LanguageEnglish
Published Headquarters IEEE 1995
Institute of Electrical and Electronics Engineers
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Abstract The Physiology Research Branch at Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on the cardiovascular system and to identify the particular mechanisms that invoke these responses. Primary investigative research efforts in a non-human primate model require the calculation of total peripheral resistance (TPR), systemic arterial compliance (SAC), and pressure-volume loop characteristics. These calculations require beat-to-beat measurement of aortic flow. We have evaluated commercially available electromagnetic (EMF) and transit-time flow measurement techniques. In vivo and in vitro experiments demonstrated that the average error of these techniques as less than 25 percent for EMF and less than 10 percent for transit-time.
AbstractList The Physiology Research Branch at Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on the cardiovascular system and to identify the particular mechanisms that invoke these responses. Primary investigative research efforts in a non-human primate model require the calculation of total peripheral resistance (TPR), systemic arterial compliance (SAC), and pressure-volume loop characteristics. These calculations require beat-to-beat measurement of aortic flow. We have evaluated commercially available electromagnetic (EMF) and transit-time flow measurement techniques. In vivo and in vitro experiments demonstrated that the average error of these techniques as less than 25 percent for EMF and less than 10 percent for transit-time.
The Physiology Research Branch of Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on the cardiovascular system and to indentify the particular mechanisms that invoke these responses. Primary investigative research efforts in a non-human primate model require the calculation of total peripheral resistance (TPR), systemic arterial compliance (SAC), and pressure-volume loop characteristics. These calculations require beat-to-beat measurement of aortic flow. We have evaluated commercially available electromagnetic (EMF) and transit-time flow measurement techniques. In vivo and in vitro experiments demonstrated that the average error of these techniques is less than 25 percent for EMF and less than 10 percent for transit-time.
Audience PUBLIC
Author Reister, C.
Fanton, J.W.
Ferguson, T.
Schaub, J.
Muniz, G.
Koenig, S.C.
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Snippet The Physiology Research Branch at Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on...
The Physiology Research Branch of Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on...
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StartPage 1573
SubjectTerms Biosensors
Cardiovascular system
Electrical resistance measurement
Electromagnetic measurements
Fluid flow measurement
Humans
Immune system
In vivo
Life Sciences (General)
Measurement techniques
Physiology
Title Evaluation of flow biosensor technology in a chronically-instrumented non-human primate model
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https://ntrs.nasa.gov/citations/19960017308
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