Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment

• Published in: Human brain mapping Vol. 36; no. 1; pp. 258 - 287
• Main Authors: Yushkevich, Paul A., Pluta, John B., Wang, Hongzhi, Xie, Long, Ding, Song-Lin, Gertje, Eske C., Mancuso, Lauren, Kliot, Daria, Das, Sandhitsu R., Wolk, David A.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2015; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Algorithms; Alzheimer's disease; Automatic Data Processing; biomarker; Brain Mapping; Brodmann area 35; Cognitive Dysfunction - pathology; cornu ammonis; entorhinal cortex; Female; hippocampus; Hippocampus - pathology; Humans; Image Processing, Computer-Assisted; Learning - physiology; Magnetic Resonance Imaging; Male; perirhinal cortex; segmentation; Temporal Lobe - pathology; cornu ammonis; magnetic resonance imaging; hippocampus; entorhinal cortex; segmentation; biomarker; Alzheimer's disease; Brodmann area 35; perirhinal cortex

We evaluate a fully automatic technique for labeling hippocampal subfields and cortical subregions in the medial temporal lobe in in vivo 3 Tesla MRI. The method performs segmentation on a T2‐weighted MRI scan with 0.4 × 0.4 × 2.0 mm3 resolution, partial brain coverage, and oblique orientation. Hipp...