An ultrasensitive CMOS magnetic biosensor array with correlated double counting noise suppression

This paper presents a scalable and ultrasensitive frequency-shift magnetic biosensing array scheme. The theoretical limit of the sensor noise floor is shown to be dominated by the phase noise of the sensing oscillators. To increase the sensitivity, a noise suppression technique, Correlated Double Co...

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Bibliographic Details
Published in2010 IEEE MTT-S International Microwave Symposium p. 1
Main Authors Wang, H., Kosai, S., Sideris, C., Hajimiri, A.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.05.2010
Subjects
Biosensors
CMOS process
Frequency
Magnetic noise
Magnetic particles
Magnetic sensors
Oscillators
Phase noise
Sensor arrays
Signal to noise ratio
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Summary:This paper presents a scalable and ultrasensitive frequency-shift magnetic biosensing array scheme. The theoretical limit of the sensor noise floor is shown to be dominated by the phase noise of the sensing oscillators. To increase the sensitivity, a noise suppression technique, Correlated Double Counting (CDC), is proposed with no extra power overhead. As an implementation example, a 64-cell sensor array is designed in a standard 65nm CMOS process. The CDC scheme achieves an additional 6dB noise suppression. The magnetic sensing capability of the presented sensor is verified by detecting micron size magnetic particles with an SNR of 14.6dB for a single bead and an effective dynamic range of at least 74.5dB.
ISBN:1424460565
9781424460564
ISSN:0149-645X
2576-7216
DOI:10.1109/MWSYM.2010.5516851