NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

• Published in: EMBO reports Vol. 17; no. 3; pp. 349 - 366
• Main Authors: Liu, Xiaofeng, Tan, Yuqin, Zhang, Chunfeng, Zhang, Ying, Zhang, Liangliang, Ren, Pengwei, Deng, Hongkui, Luo, Jianyuan, Ke, Yang, Du, Xiaojuan
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.03.2016; Nature Publishing Group UK; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Acetylation; Active Transport, Cell Nucleus; Apoptosis; Cell cycle; Cell Nucleus - metabolism; Colorectal cancer; Colorectal Neoplasms - metabolism; Deoxyribonucleic acid; DNA; DNA Damage; E3 ligase; EMBO31; EMBO37; Genomes; HCT116 Cells; HEK293 Cells; Humans; Mdm2; N-Terminal Acetyltransferase E - genetics; N-Terminal Acetyltransferase E - metabolism; N-Terminal Acetyltransferases; NAT10; p53; Protein Binding; Protein Stability; Proteolysis; Proto-Oncogene Proteins c-mdm2 - metabolism; Tumor Suppressor Protein p53 - metabolism; Ubiquitination; acetylation; Mdm2; NAT10; E3 ligase; p53

As a genome guardian, p53 maintains genome stability by arresting cells for damage repair or inducing cell apoptosis to eliminate the damaged cells in stress response. Several nucleolar proteins stabilize p53 by interfering Mdm2–p53 interaction upon cellular stress, while other mechanisms by which n...