SLFN11 inhibits checkpoint maintenance and homologous recombination repair

• Published in: EMBO reports Vol. 17; no. 1; pp. 94 - 109
• Main Authors: Mu, Yanhua, Lou, Jiangman, Srivastava, Mrinal, Zhao, Bin, Feng, Xin-hua, Liu, Ting, Chen, Junjie, Huang, Jun
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.01.2016; Nature Publishing Group UK; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Biomarkers; Cancer therapies; Cell Cycle Checkpoints; Cell Line, Tumor; checkpoint initiation; checkpoint maintenance; Deoxyribonucleic acid; DNA; DNA Damage; DNA damage response; DNA Replication; DNA, Single-Stranded - genetics; DNA, Single-Stranded - metabolism; EMBO03; EMBO13; Genes, cdc; HeLa Cells; homologous recombination repair; Humans; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Proteins; Recombinational DNA Repair; Replication Protein A - genetics; Replication Protein A - metabolism; RPA; checkpoint initiation; RPA; checkpoint maintenance; DNA damage response; homologous recombination repair

High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA‐damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1‐dependent manner. Furthermo...