Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

• Published in: The EMBO journal Vol. 30; no. 8; pp. 1425 - 1432
• Main Authors: Mohammadi, Tamimount, van Dam, Vincent, Sijbrandi, Robert, Vernet, Thierry, Zapun, André, Bouhss, Ahmed, Diepeveen-de Bruin, Marlies, Nguyen-Distèche, Martine, de Kruijff, Ben, Breukink, Eefjan
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 20.04.2011; Nature Publishing Group UK; Springer Nature B.V; Nature Publishing Group
• Subjects: antibiotic target; Bacteria; Bacterial Proteins - metabolism; Biological Transport; Cell Membrane - metabolism; Cell Wall - metabolism; cell wall synthesis; Cells; E coli; EMBO05; EMBO20; Escherichia coli; Escherichia coli - metabolism; flippase activity; FtsW; Lipid II; Lipids; Membrane Lipids - metabolism; Membrane Proteins - metabolism; Membranes; Peptidoglycan - metabolism; Recombinant Proteins - metabolism; Translocation; antibiotic target; Lipid II; FtsW; cell wall synthesis; flippase activity

Bacterial cell growth necessitates synthesis of peptidoglycan. Assembly of this major constituent of the bacterial cell wall is a multistep process starting in the cytoplasm and ending in the exterior cell surface. The intracellular part of the pathway results in the production of the membrane‐ancho...