Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis

• Published in: Oral diseases Vol. 21; no. 5; pp. 645 - 651
• Main Authors: Oouchi, M, Hasebe, A, Hata, H, Segawa, T, Yamazaki, Y, Yoshida, Y, Kitagawa, Y, Shibata, K-I
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.07.2015; Wiley Subscription Services, Inc
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; Candida albicans - isolation & purification; Candidiasis, Oral - immunology; Candidiasis, Oral - microbiology; Disease Progression; Down-Regulation; Female; Flow Cytometry; Fungal infections; Humans; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; natural killer cell activity; oral candidiasis; Oral diseases; toll-like receptors; Toll-Like Receptors - biosynthesis; Toll-Like Receptors - immunology; Toll-Like Receptors - metabolism; toll-like receptors; natural killer cell activity; oral candidiasis

Objective Roles of aging or immune responses mediated by Toll‐like receptors and natural killer cell in the onset or progression of human candidiasis remain unclear. This study was designed to elucidate the roles using peripheral blood mononuclear cells from healthy donors and patients with oral can...