Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain

• Published in: Brain pathology (Zurich, Switzerland) Vol. 23; no. 4; pp. 378 - 389
• Main Authors: Lund, Harald, Cowburn, Richard F., Gustafsson, Elin, Strömberg, Kia, Svensson, Anne, Dahllund, Leif, Malinowsky, David, Sunnemark, Dan
• Format: Journal Article
• Language: English
• Published: Switzerland Blackwell Publishing Ltd 01.07.2013; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer's disease; Brain - metabolism; Brain - pathology; Dendrites - metabolism; Dendrites - pathology; Female; Gene Expression Regulation - physiology; HEK293 Cells; Humans; Male; Medicin och hälsovetenskap; neurofibrillary tangles; Neurofibrillary Tangles - metabolism; Neurofibrillary Tangles - pathology; Neurons; Neurons - metabolism; Neurons - pathology; Phosphorylation; Phosphorylation - genetics; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; RNA, Messenger - metabolism; Serine - metabolism; tau phosphorylation; tau Proteins - genetics; tau Proteins - metabolism; tau-tubulin kinase 1; Transfection

Recent reports have implicated tau‐tubulin kinase 1 (TTBK1) in the pathological phosphorylation of tau that occurs in Alzheimer's disease (AD). The present study was undertaken to provide an extensive characterization of TTBK1 mRNA and protein expression in human brain from AD cases and non‐dem...