Molecular Design, Structures, and Activity of Antimicrobial Peptide-Mimetic Polymers

• Published in: Macromolecular bioscience Vol. 13; no. 10; pp. 1285 - 1299
• Main Authors: Takahashi, Haruko, Palermo, Edmund F., Yasuhara, Kazuma, Caputo, Gregory A., Kuroda, Kenichi
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.10.2013
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - therapeutic use; Antiinfectives and antibacterials; Antimicrobial Cationic Peptides - chemical synthesis; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - therapeutic use; antimicrobial materials; Bacteria; Biomedical materials; Biomimetics; Cationic; Copolymers; Escherichia coli; Escherichia coli - drug effects; Flexibility; Humans; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - pathogenicity; Microbial Sensitivity Tests; Molecular structure; peptides; Polymers; Polymers - chemical synthesis; Polymers - chemistry; Polymers - therapeutic use; Staphylococcus aureus; Structure-Activity Relationship; structure-property relations; copolymers; structure-property relations; peptides; antimicrobial materials; biomimetics

There is an urgent need for new antibiotics which are effective against drug‐resistant bacteria without contributing to resistance development. We have designed and developed antimicrobial copolymers with cationic amphiphilic structures based on the mimicry of naturally occurring antimicrobial pepti...