A review of disease progression models of Parkinson's disease and applications in clinical trials

• Published in: Movement disorders Vol. 31; no. 7; pp. 947 - 956
• Main Authors: Venuto, Charles S., Potter, Nicholas B., Ray Dorsey, E., Kieburtz, Karl
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2016; Wiley Subscription Services, Inc
• Subjects: disease model; Disease Progression; Humans; Models, Theoretical; Movement disorders; Parkinson Disease; Parkinson's disease; pharmacometrics; UPDRS; UPDRS; Parkinson's disease; disease progression; pharmacometrics; disease model

ABSTRACT Quantitative disease progression models for neurodegenerative disorders are gaining recognition as important tools for drug development and evaluation. In Parkinson's disease (PD), several models have described longitudinal changes in the Unified Parkinson's Disease Rating Scale (...