Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy

• Published in: Human brain mapping Vol. 36; no. 3; pp. 1165 - 1179
• Main Authors: Planetta, Peggy J., Kurani, Ajay S., Shukla, Priyank, Prodoehl, Janey, Corcos, Daniel M., Comella, Cynthia L., McFarland, Nikolaus R., Okun, Michael S., Vaillancourt, David E.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2015; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Aged; Atrophy - pathology; atypical parkinsonism; Basal Ganglia - pathology; Basal Ganglia - physiopathology; Brain - pathology; Brain - physiopathology; brain atrophy; Cerebellum - pathology; Cerebellum - physiopathology; Cerebrum - pathology; Cerebrum - physiopathology; Female; force; functional magnetic resonance imaging; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple System Atrophy - pathology; Multiple System Atrophy - physiopathology; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Psychomotor Performance - physiology; voxel-based morphometry; magnetic resonance imaging; Parkinson's disease; atypical parkinsonism; brain atrophy; force; voxel-based morphometry; functional magnetic resonance imaging

Parkinson's disease (PD) and the parkinsonian variant of multiple system atrophy (MSAp) are neurodegenerative disorders that can be difficult to differentiate clinically. This study provides the first characterization of the patterns of task‐related functional magnetic resonance imaging (fMRI)...