Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model

• Published in: Wound repair and regeneration Vol. 21; no. 1; pp. 35 - 43
• Main Authors: Bohr, Stefan, Patel, Suraj J, Sarin, Dhruv, Irimia, Daniel, Yarmush, Martin L., Berthiaume, Francois
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2013
• Subjects: Animals; Burns - pathology; Burns - therapy; Disease Models, Animal; Docosahexaenoic Acids - pharmacology; Female; Inflammation - pathology; Inflammation - therapy; Interleukin-1beta - metabolism; Male; Mice; Mice, Inbred C57BL; Microvessels; Necrosis - pathology; Necrosis - therapy; Neutrophils - metabolism; Skin - blood supply; Skin - pathology; Thrombosis - pathology; Thrombosis - therapy; Tumor Necrosis Factor-alpha - metabolism; Wound Healing - drug effects
• ISSN: 1067-1927; 1524-475X; 1524-475X
• DOI: 10.1111/j.1524-475X.2012.00853.x

Deep partial thickness burns are subject to delayed necrosis of initially viable tissues surrounding the primary zone of thermally induced coagulation, which results in an expansion of the burn wound, both in area and depth, within 48 hours postburn. Neutrophil sequestration and activation leading t...