Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne

• Published in: British journal of dermatology (1951) Vol. 165; no. 2; pp. 302 - 310
• Main Authors: Lumsden, K.R., Nelson, A.M., Dispenza, M.C., Gilliland, K.L., Cong, Z., Zaenglein, A.L., Thiboutot, D.M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011; Wiley-Blackwell
• Subjects: Acne Vulgaris - drug therapy; Acne Vulgaris - metabolism; Acute-Phase Proteins - metabolism; Adolescent; Adult; Biological and medical sciences; Cells, Cultured; Cohort Studies; Dermatologic Agents - therapeutic use; Dermatology; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-1beta - pharmacology; Interleukin-8 - metabolism; Isotretinoin - therapeutic use; Lipocalin-2; Lipocalins - metabolism; Medical sciences; Propionibacterium acnes - isolation & purification; Propionibacterium acnes - metabolism; Proto-Oncogene Proteins - metabolism; Sebaceous Glands - cytology; Sebaceous Glands - metabolism; Skin - metabolism; Skin - microbiology; Skin involvement in other diseases. Miscellaneous. General aspects; Young Adult; Human; Skin disease; Treatment; Dermatology; Acne; Antiacneic agent; Isotretinoin; Skin; Neutrophil

Summary Background  A clear‐cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. Lack of data regarding the specifics of isotretinoin’s mechanism of action has hampered progress in this area. Recently, the protein neutrophil gelatinase‐associated lipocalin (...