The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

• Published in: Addiction (Abingdon, England) Vol. 106; no. 11; pp. 1978 - 1988
• Main Authors: Turner, Katy M. E., Hutchinson, Sharon, Vickerman, Peter, Hope, Vivian, Craine, Noel, Palmateer, Norah, May, Margaret, Taylor, Avril, De Angelis, Daniela, Cameron, Sheila, Parry, John, Lyons, Margaret, Goldberg, David, Allen, Elizabeth, Hickman, Matthew
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2011; Blackwell
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Blood Diseases; Disease control; Disease Transmission, Infectious - prevention & control; Drug Abuse; Drug addiction; Drug use; Drug users; Epidemiologic Methods; Evidence; Female; Glasgow, Scotland; Harm Reduction; HCV; Hepatitis; Hepatitis C; Hepatitis C - epidemiology; Hepatitis C - prevention & control; Hepatitis C - transmission; Hepatitis C virus; Homelessness; Humans; Intervention; Male; Medical care; Medical sciences; Medical treatment; Meta-analysis; methadone; Methadone - therapeutic use; Miscellaneous; Narcotics - therapeutic use; needle and syringe programmes; Needle exchange programs; Needle Sharing - adverse effects; Needle Sharing - statistics & numerical data; Opiate Substitution Treatment; Opiates; Outcome Assessment, Health Care; Population; Prevention and actions; primary prevention; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression analysis; Risk; Sick Role; Substance abuse treatment; Substance Abuse, Intravenous - epidemiology; Substance Abuse, Intravenous - rehabilitation; Surveys; Systematic review; United Kingdom; United Kingdom - epidemiology; United Kingdom; Europe; United Kingdom > UK; British Isles, England, Avon, Bristol; British Isles, Wales; British Isles, England, Greater London, London; British Isles, Scotland, Glasgow; Human; Drug addiction; Replacement therapy; Intravenous administration; Illicit drug; Opiates; Methadone; Narcotic analgesic; needle and syringe programmes; Incidence; Virus; Prevention; Addiction; Needle; Syringe; primary prevention; opiate substitution treatment; HCV; Flaviviridae; Hepatitis C virus; Hepacivirus; Public health

ABSTRACT Aims  To investigate whether opiate substitution therapy (OST) and needle and syringe programmes (NSP) can reduce hepatitis C virus (HCV) transmission among injecting drug users (IDUs). Design  Meta‐analysis and pooled analysis, with logistic regression allowing adjustment for gender, injec...