ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases
FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal‐lysosomal pathway. Mutations of FIG4 lead to the development of Charcot‐Marie‐Tooth disease type 4J and amyotrophic lateral sclerosis (ALS). Moreover, ALS‐associated proteins (transactivation response DNA prot...
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| Published in | Neuropathology Vol. 34; no. 1; pp. 19 - 26 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Australia
Blackwell Publishing Ltd
01.02.2014
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0919-6544 1440-1789 1440-1789 |
| DOI | 10.1111/neup.12056 |
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| Abstract | FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal‐lysosomal pathway. Mutations of FIG4 lead to the development of Charcot‐Marie‐Tooth disease type 4J and amyotrophic lateral sclerosis (ALS). Moreover, ALS‐associated proteins (transactivation response DNA protein 43 (TDP‐43), fused in sarcoma (FUS), optineurin, ubiquilin‐2, charged mutivesicular body protein 2b (CHMP2B) and valosin‐containing protein) are involved in inclusion body formation in several neurodegenerative diseases. Using immunohistochemistry, we examined the brains and spinal cords of patients with various neurodegenerative diseases, including sporadic TDP‐43 proteinopathy (ALS and frontotemporal lobar degeneration). TDP‐43 proteinopathy demonstrated no FIG4 immunoreactivity in neuronal inclusions. However, FIG4 immunoreactivity was present in Pick bodies in Pick's disease, Lewy bodies in Parkinson's disease and dementia with Lewy bodies, neuronal nuclear inclusions in polyglutamine and intranuclear inclusion body diseases, and Marinesco and Hirano bodies in aged control subjects. These findings suggest that FIG4 is not incorporated in TDP‐43 inclusions and that it may have a common role in the formation or degradation of neuronal cytoplasmic and nuclear inclusions in several neurodegenerative diseases. |
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| AbstractList | FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal‐lysosomal pathway. Mutations of FIG4 lead to the development of Charcot‐Marie‐Tooth disease type 4J and amyotrophic lateral sclerosis (ALS). Moreover, ALS‐associated proteins (transactivation response DNA protein 43 (TDP‐43), fused in sarcoma (FUS), optineurin, ubiquilin‐2, charged mutivesicular body protein 2b (CHMP2B) and valosin‐containing protein) are involved in inclusion body formation in several neurodegenerative diseases. Using immunohistochemistry, we examined the brains and spinal cords of patients with various neurodegenerative diseases, including sporadic TDP‐43 proteinopathy (ALS and frontotemporal lobar degeneration). TDP‐43 proteinopathy demonstrated no FIG4 immunoreactivity in neuronal inclusions. However, FIG4 immunoreactivity was present in Pick bodies in Pick's disease, Lewy bodies in Parkinson's disease and dementia with Lewy bodies, neuronal nuclear inclusions in polyglutamine and intranuclear inclusion body diseases, and Marinesco and Hirano bodies in aged control subjects. These findings suggest that FIG4 is not incorporated in TDP‐43 inclusions and that it may have a common role in the formation or degradation of neuronal cytoplasmic and nuclear inclusions in several neurodegenerative diseases. FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal-lysosomal pathway. Mutations of FIG4 lead to the development of Charcot-Marie-Tooth disease type 4J and amyotrophic lateral sclerosis (ALS). Moreover, ALS-associated proteins (transactivation response DNA protein 43 (TDP-43), fused in sarcoma (FUS), optineurin, ubiquilin-2, charged mutivesicular body protein 2b (CHMP2B) and valosin-containing protein) are involved in inclusion body formation in several neurodegenerative diseases. Using immunohistochemistry, we examined the brains and spinal cords of patients with various neurodegenerative diseases, including sporadic TDP-43 proteinopathy (ALS and frontotemporal lobar degeneration). TDP-43 proteinopathy demonstrated no FIG4 immunoreactivity in neuronal inclusions. However, FIG4 immunoreactivity was present in Pick bodies in Pick's disease, Lewy bodies in Parkinson's disease and dementia with Lewy bodies, neuronal nuclear inclusions in polyglutamine and intranuclear inclusion body diseases, and Marinesco and Hirano bodies in aged control subjects. These findings suggest that FIG4 is not incorporated in TDP-43 inclusions and that it may have a common role in the formation or degradation of neuronal cytoplasmic and nuclear inclusions in several neurodegenerative diseases.FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal-lysosomal pathway. Mutations of FIG4 lead to the development of Charcot-Marie-Tooth disease type 4J and amyotrophic lateral sclerosis (ALS). Moreover, ALS-associated proteins (transactivation response DNA protein 43 (TDP-43), fused in sarcoma (FUS), optineurin, ubiquilin-2, charged mutivesicular body protein 2b (CHMP2B) and valosin-containing protein) are involved in inclusion body formation in several neurodegenerative diseases. Using immunohistochemistry, we examined the brains and spinal cords of patients with various neurodegenerative diseases, including sporadic TDP-43 proteinopathy (ALS and frontotemporal lobar degeneration). TDP-43 proteinopathy demonstrated no FIG4 immunoreactivity in neuronal inclusions. However, FIG4 immunoreactivity was present in Pick bodies in Pick's disease, Lewy bodies in Parkinson's disease and dementia with Lewy bodies, neuronal nuclear inclusions in polyglutamine and intranuclear inclusion body diseases, and Marinesco and Hirano bodies in aged control subjects. These findings suggest that FIG4 is not incorporated in TDP-43 inclusions and that it may have a common role in the formation or degradation of neuronal cytoplasmic and nuclear inclusions in several neurodegenerative diseases. |
| Author | Wakabayashi, Koichi Kakita, Akiyoshi Kon, Tomoya Toyoshima, Yasuko Tanji, Kunikazu Takahashi, Hitoshi Miki, Yasuo Sasaki, Hidenao Mori, Fumiaki Yoshida, Mari |
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| Copyright | 2013 Japanese Society of Neuropathology 2013 Japanese Society of Neuropathology. Copyright © 2014 Japanese Society of Neuropathology |
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| Keywords | FIG4 endosomal-lysosomal pathway nuclear inclusion Lewy body Pick body |
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| References_xml | – reference: Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neuritis in Alzhermer's disease brains. Neuropathol Appl Neurobiol 2013. doi: 10.1111/nan.12036 – reference: Suzuki K, Ohsumi Y. Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 2007; 581: 2156-2161. – reference: Chow CY, Landers JE, Bergren SK et al. Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet 2009; 84: 85-88. – reference: Jones AL, Quimby BB, Hood JK et al. SAC3 may link nuclear protein export to cell cycle progression. Proc Natl Acad Sci USA 2000; 97: 3224-3229. – reference: Nishie M, Mori F, Fujiwara H et al. Accumulation of phosphorylated α-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 2004; 107: 292-298. – reference: Tan C-F, Yamada M, Toyoshima Y et al. Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease. Acta Neuropathol 2009; 118: 553-560. – reference: Oyanagi S. A Guide to Neuropathology by Electron Microscopy, 1st edn. Tokyo: Igaku Shoin, 1992. – reference: Odagiri S, Tanji K, Mori F et al. Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation. Neuropathology 2012; 32: 261-266. – reference: Beach TG, Walker DG, Sue LL, Newell A, Adler CC, Joyce JN. Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers. J Neuropathol Exp Neurol 2004; 63: 329-337. – reference: Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011; 7: 279-296. – reference: Mori F, Tanji K, Odagiri S et al. Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. Acta Neuropathol 2012; 124: 149-151. – reference: N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, Brown EJ. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep 2009; 10: 173-179. – reference: Ferguson CJ, Lenk GM, Jones JM et al. Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration. Hum Mol Genet 2012; 21: 3525-3534. – reference: Viswanathan J, Haapasalo A, Böttcher C et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 2011; 12: 330-348. – reference: Takahashi T, Katada S, Onodera O. Polyglutamine diseases: where does toxicity come from? What is toxicity? Where are we going? J Mol Cell Biol 2010; 2: 180-191. – reference: Martinez-Vicente M, Cuervo AM. 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| Snippet | FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal‐lysosomal pathway. Mutations of FIG4 lead to the development of... FIG4 is a phosphatase that regulates intracellular vesicle trafficking along the endosomal-lysosomal pathway. Mutations of FIG4 lead to the development of... |
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| SubjectTerms | Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - enzymology Amyotrophic Lateral Sclerosis - pathology Brain - enzymology Brain - pathology Disease endosomal-lysosomal pathway FIG4 Flavoproteins - analysis Humans Intranuclear Inclusion Bodies - enzymology Intranuclear Inclusion Bodies - pathology Lewy Bodies - enzymology Lewy Bodies - pathology Lewy body Medical research Middle Aged Neurodegenerative Diseases - enzymology Neurodegenerative Diseases - pathology Neurons - enzymology Neurons - pathology nuclear inclusion Peptides - metabolism Phosphoric Monoester Hydrolases - analysis Pick body Pick Disease of the Brain - enzymology Pick Disease of the Brain - pathology Proteins |
| Title | ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases |
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