MicroRNA function in NK-cell biology

Summary The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the...

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Published inImmunological reviews Vol. 253; no. 1; pp. 40 - 52
Main Authors Beaulieu, Aimee M., Bezman, Natalie A., Lee, Jang Eun, Matloubian, Mehrdad, Sun, Joseph C., Lanier, Lewis L.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.05.2013
Subjects
Animals
Cell Differentiation - genetics
cytotoxicity
Cytotoxicity, Immunologic - genetics
development
Homeostasis
Humans
Immune System Diseases - genetics
Immune System Diseases - immunology
Immunomodulation
Killer Cells, Natural - immunology
microRNA
MicroRNAs - genetics
MicroRNAs - immunology
natural killer
Neoplasms - genetics
Neoplasms - immunology
RNA Interference - immunology
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Summary:Summary The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation.
Bibliography:istex:680208FC865FD3725340B8BAD181194CF008C323
ArticleID:IMR12045
NIH - No. CA009149; No. AI085034; No. AI100874; No. AI068129
ark:/67375/WNG-W7XTHZ68-J
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Feature-1
ISSN:0105-2896
1600-065X
DOI:10.1111/imr.12045