The RtcB RNA ligase is an essential component of the metazoan unfolded protein response
RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans...
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| Published in | EMBO reports Vol. 15; no. 12; pp. 1278 - 1285 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Blackwell Publishing Ltd
01.12.2014
Nature Publishing Group UK Springer Nature B.V BlackWell Publishing Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel
in vivo
model in
Caenorhabditis elegans
for the conserved RNA ligase RtcB and show that RtcB ligates the
xbp‐1
mRNA during the IRE‐1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated
xbp‐1
mRNA fragments
,
defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre‐tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre‐spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both
xbp‐1
and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes
in vivo
.
Synopsis
Work in
C. elegans
shows that RtcB is the RNA ligase for
xbp‐1
splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development.
RtcB ligates endogenous intron‐containing tRNAs
in vivo
.
RtcB is the sole ligase for
xbp‐1
splicing in the UPR.
The tRNA and
xbp‐1
functions of RtcB can be separated using animals engineered to express intron‐free tRNAs.
Graphical Abstract
Work in
C. elegans
shows that RtcB is the RNA ligase for
xbp‐1
splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. |
|---|---|
| AbstractList | RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp-1 mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp-1 mRNA fragments, defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre-tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre-spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp-1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo. RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp-1mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp-1mRNA fragments, defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre-tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre-spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp-1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo. Synopsis Work in C. elegans shows that RtcB is the RNA ligase for xbp-1 splicing in the IRE-1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. RtcB ligates endogenous intron-containing tRNAs in vivo. RtcB is the sole ligase for xbp-1 splicing in the UPR. The tRNA and xbp-1 functions of RtcB can be separated using animals engineered to express intron-free tRNAs. RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp-1 mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp-1 mRNA fragments, defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre-tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre-spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp-1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo.RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp-1 mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp-1 mRNA fragments, defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre-tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre-spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp-1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo. RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp‐1 mRNA during the IRE‐1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp‐1 mRNA fragments, defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre‐tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre‐spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp‐1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo. Synopsis Work in C. elegans shows that RtcB is the RNA ligase for xbp‐1 splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. RtcB ligates endogenous intron‐containing tRNAs in vivo. RtcB is the sole ligase for xbp‐1 splicing in the UPR. The tRNA and xbp‐1 functions of RtcB can be separated using animals engineered to express intron‐free tRNAs. Work in C. elegans shows that RtcB is the RNA ligase for xbp‐1 splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp-1 mRNA during the IRE-1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp-1 mRNA fragments , defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre-tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre-spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp-1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo . Subject Categories Protein Biosynthesis & Quality Control; RNA Biology RNA ligation can regulate RNA function by altering RNA sequence, structure and coding potential. For example, the function of XBP1 in mediating the unfolded protein response requires RNA ligation, as does the maturation of some tRNAs. Here, we describe a novel in vivo model in Caenorhabditis elegans for the conserved RNA ligase RtcB and show that RtcB ligates the xbp‐1 mRNA during the IRE‐1 branch of the unfolded protein response. Without RtcB, protein stress results in the accumulation of unligated xbp‐1 mRNA fragments , defects in the unfolded protein response, and decreased lifespan. RtcB also ligates endogenous pre‐tRNA halves, and RtcB mutants have defects in growth and lifespan that can be bypassed by expression of pre‐spliced tRNAs. In addition, animals that lack RtcB have defects that are independent of tRNA maturation and the unfolded protein response. Thus, RNA ligation by RtcB is required for the function of multiple endogenous target RNAs including both xbp‐1 and tRNAs. RtcB is uniquely capable of performing these ligation functions, and RNA ligation by RtcB mediates multiple essential processes in vivo . Synopsis Work in C. elegans shows that RtcB is the RNA ligase for xbp‐1 splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. RtcB ligates endogenous intron‐containing tRNAs in vivo . RtcB is the sole ligase for xbp‐1 splicing in the UPR. The tRNA and xbp‐1 functions of RtcB can be separated using animals engineered to express intron‐free tRNAs. Graphical Abstract Work in C. elegans shows that RtcB is the RNA ligase for xbp‐1 splicing in the IRE‐1 branch of the UPR. RtcB also ligates endogenous tRNA substrates and promotes lifespan and development. |
| Author | Han, Sung Min Eckwahl, Matthew J Meyer, Benjamin Isaiah Hesselberth, Jay R Wolin, Sandra L Peach, Sally Kosmaczewski, Sara Guckian Hammarlund, Marc Edwards, Tyson James |
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| Keywords | HSPC117 tRNA RtcB Caenorhabditis elegans xbp‐1 |
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Mol Cell 43: 613-623 Ivanov, Emara, Villen, Gygi, Anderson (CR17) 2011; 43 Tarn, Yario, Steitz (CR32) 1995; 1 Filipowicz, Konarska, Gross, Shatkin (CR1) 1983; 11 Kaine, Gupta, Woese (CR13) 1983; 80 Kanai, Dohmae, Hirokawa (CR29) 2004; 43 Yoshida (CR21) 2007; 9 Calfon, Zeng, Urano, Till, Hubbard, Harding, Clark, Ron (CR6) 2002; 415 Gonzalez, Sidrauski, Dörfler, Walter (CR28) 1999; 18 Shen, Ellis, Lee, Liu, Yang, Solomon, Yoshida, Morimoto, Kurnit, Mori (CR5) 2001; 107 Knapp, Beckmann, Johnson, Fuhrman, Abelson (CR12) 1978; 14 Laski, Fire, RajBhandary, Sharp (CR3) 1983; 258 Hamamichi, Rivas, Knight, Cao, Caldwell, Caldwell (CR27) 2008; 105 Frøkjær‐Jensen, Davis, Ailion, Jorgensen (CR31) 2012; 9 Hanada, Weitzer, Mair, Bernreuther, Wainger, Ichida, Hanada, Orthofer, Cronin, Komnenovic (CR26) 2013; 495 Silber, Malathi, Hurwitz (CR7) 1972; 69 Cox, Walter (CR19) 1996; 87 Taylor, Dillin (CR33) 2013; 153 Lu, Liang, Wang (CR24) 2014; 55 Greer, Peebles, Gegenheimer, Abelson (CR9) 1983; 32 Englert, Sheppard, Aslanian, Yates, Söll (CR15) 2011; 108 Chan, Lowe (CR14) 2009; 37 Emara, Ivanov, Hickman, Dawra, Tisdale, Kedersha, Hu, Anderson (CR16) 2010; 285 Popow, Englert, Weitzer, Schleiffer, Mierzwa, Mechtler, Trowitzsch, Will, Lührmann, Söll (CR10) 2011; 331 Tanaka, Meineke, Shuman (CR20) 2011; 286 Qabazard, Ahmed, Li, Arlt, Moore, Stürzenbaum (CR22) 2013; 8 Frøkjaer‐Jensen, Davis, Hopkins, Newman, Thummel, Olesen, Grunnet, Jorgensen (CR30) 2008; 40 Englert, Beier (CR8) 2005; 33 Saikia, Krokowski, Guan, Ivanov, Parisien, Hu, Anderson, Pan, Hatzoglou (CR25) 2012; 287 Popow, Schleiffer, Martinez (CR11) 2012; 69 Paushkin, Patel, Furia, Peltz, Trotta (CR4) 2004; 117 Pan, Palter, Rogers, Olsen, Chen, Lithgow, Kapahi (CR23) 2007; 6 Filipowicz, Shatkin (CR2) 1983; 32 Nwagwu, Nana (CR18) 1980; 56 2004; 43 1983; 258 2012; 287 1983; 32 2002; 415 2010; 285 2008; 105 1978; 14 1972; 69 2001; 107 2013; 8 1995; 1 2011; 331 1983; 11 2011; 108 1999; 18 1980; 56 2007; 9 2007; 6 2011; 43 1983; 80 2013; 495 2013; 153 2012; 69 2008; 40 2004; 117 2005; 33 1996; 87 2009; 37 2014; 55 2011; 286 2012; 9 18984615 - Nucleic Acids Res. 2009 Jan;37(Database issue):D93-7 21855800 - Mol Cell. 2011 Aug 19;43(4):613-23 23474986 - Nature. 2013 Mar 28;495(7442):474-80 352537 - Cell. 1978 Jun;14(2):221-36 8898193 - Cell. 1996 Nov 1;87(3):391-404 23791175 - Cell. 2013 Jun 20;153(7):1435-47 6413507 - J Biol Chem. 1983 Oct 10;258(19):11974-80 15312650 - Neuron. 2004 Aug 19;43(4):513-25 17266680 - Aging Cell. 2007 Feb;6(1):111-9 23086926 - J Biol Chem. 2012 Dec 14;287(51):42708-25 7400745 - J Embryol Exp Morphol. 1980 Apr;56:253-67 22290181 - Nat Methods. 2012 Feb;9(2):117-8 11780124 - Nature. 2002 Jan 3;415(6867):92-6 6828385 - Nucleic Acids Res. 1983 Mar 11;11(5):1405-18 21757685 - J Biol Chem. 2011 Sep 2;286(35):30253-7 18182484 - Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):728-33 21311021 - Science. 2011 Feb 11;331(6018):760-4 25404664 - EMBO J. 2014 Dec 17;33(24):2887-9 11779465 - Cell. 2001 Dec 28;107(7):893-903 6304706 - Proc Natl Acad Sci U S A. 1983 Jun;80(11):3309-12 15109492 - Cell. 2004 Apr 30;117(3):311-21 20129916 - J Biol Chem. 2010 Apr 2;285(14):10959-68 24260346 - PLoS One. 2013;8(11):e80135 25087875 - Mol Cell. 2014 Sep 4;55(5):758-70 18953339 - Nat Genet. 2008 Nov;40(11):1375-83 17979529 - Antioxid Redox Signal. 2007 Dec;9(12):2323-33 4342972 - Proc Natl Acad Sci U S A. 1972 Oct;69(10):3009-13 7489523 - RNA. 1995 Aug;1(6):644-56 15653639 - Nucleic Acids Res. 2005;33(1):388-99 6186399 - Cell. 1983 Feb;32(2):547-57 6297798 - Cell. 1983 Feb;32(2):537-46 21209330 - Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1290-5 10357823 - EMBO J. 1999 Jun 1;18(11):3119-32 22426497 - Cell Mol Life Sci. 2012 Aug;69(16):2657-70 |
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CR3 article-title: Characterization of tRNA precursor splicing in mammalian extracts publication-title: J Biol Chem – volume: 331 start-page: 760 year: 2011 end-page: 764 ident: CR10 article-title: HSPC117 is the essential subunit of a human tRNA splicing ligase complex publication-title: Science – volume: 9 start-page: 117 year: 2012 end-page: 118 ident: CR31 article-title: Improved Mos1‐mediated transgenesis in publication-title: Nat Methods – volume: 415 start-page: 92 year: 2002 end-page: 96 article-title: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP‐1 mRNA publication-title: Nature – volume: 69 start-page: 2657 year: 2012 end-page: 2670 article-title: Diversity and roles of (t)RNA ligases publication-title: Cell Mol Life Sci – volume: 80 start-page: 3309 year: 1983 end-page: 3312 article-title: Putative introns in tRNA genes of prokaryotes publication-title: Proc Natl Acad Sci USA – volume: 69 start-page: 3009 year: 1972 end-page: 3013 article-title: Purification and properties of bacteriophage T4‐induced RNA ligase publication-title: Proc Natl Acad Sci USA – volume: 6 start-page: 111 year: 2007 end-page: 119 article-title: Inhibition of mRNA translation extends lifespan in publication-title: Aging Cell – volume: 9 start-page: 117 year: 2012 end-page: 118 article-title: Improved Mos1‐mediated transgenesis in publication-title: Nat Methods – volume: 37 start-page: D93 year: 2009 end-page: D97 article-title: GtRNAdb: a database of transfer RNA genes detected in genomic sequence publication-title: Nucl Acids Res – volume: 153 start-page: 153 year: 2013 end-page: 1447 article-title: XBP‐1 is a cell‐nonautonomous regulator of stress resistance and longevity publication-title: Cell – volume: 258 start-page: 11974 year: 1983 end-page: 11980 article-title: Characterization of tRNA precursor splicing in mammalian extracts publication-title: J Biol Chem – volume: 495 start-page: 474 year: 2013 end-page: 480 article-title: CLP1 links tRNA metabolism to progressive motor‐neuron loss publication-title: Nature – volume: 331 start-page: 760 year: 2011 end-page: 764 article-title: HSPC117 is the essential subunit of a human tRNA splicing ligase complex publication-title: Science – volume: 14 start-page: 221 year: 1978 end-page: 236 article-title: Transcription and processing of intervening sequences in yeast tRNA genes publication-title: Cell – volume: 43 start-page: 513 year: 2004 end-page: 525 article-title: Kinesin transports RNA: isolation and characterization of an RNA‐transporting granule publication-title: Neuron – volume: 56 start-page: 253 year: 1980 end-page: 267 article-title: Ribonucleic acid synthesis in embryonic chick muscle, rates of synthesis and half‐lives of transfer and ribosomal RNA species publication-title: J Embryol Exp Morphol – volume: 18 start-page: 3119 year: 1999 end-page: 3132 article-title: Mechanism of non‐spliceosomal mRNA splicing in the unfolded protein response pathway publication-title: EMBO J – volume: 105 start-page: 728 year: 2008 end-page: 733 article-title: Hypothesis‐based RNAi screening identifies neuroprotective genes in a Parkinson's disease model publication-title: Proc Natl Acad Sci USA – volume: 33 start-page: 388 year: 2005 end-page: 399 article-title: Plant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic origins publication-title: Nucleic Acids Res – volume: 107 start-page: 893 year: 2001 end-page: 903 article-title: Complementary signaling pathways regulate the unfolded protein response and are required for development publication-title: Cell – volume: 43 start-page: 613 year: 2011 end-page: 623 article-title: Angiogenin‐induced tRNA fragments inhibit translation initiation publication-title: Mol Cell – volume: 286 start-page: 30253 year: 2011 end-page: 30257 article-title: RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA 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article-title: U12 snRNA in vertebrates: evolutionary conservation of 5′ sequences implicated in splicing of pre‐mRNAs containing a minor class of introns publication-title: RNA – volume: 32 start-page: 547 year: 1983 end-page: 557 article-title: Origin of splice junction phosphate in tRNAs processed by HeLa cell extract publication-title: Cell – volume: 32 start-page: 537 year: 1983 end-page: 546 article-title: Mechanism of action of a yeast RNA ligase in tRNA splicing publication-title: Cell – volume: 87 start-page: 391 year: 1996 end-page: 404 article-title: A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response publication-title: Cell – volume: 287 start-page: 42708 year: 2012 end-page: 42725 article-title: Genome‐wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress publication-title: J Biol Chem – volume: 117 start-page: 311 year: 2004 end-page: 321 article-title: Identification 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| Title | The RtcB RNA ligase is an essential component of the metazoan unfolded protein response |
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