Porphyromonas gingivalis RagB is a proinflammatory signal transducer and activator of transcription 4 agonist

• Published in: Molecular oral microbiology Vol. 30; no. 3; pp. 242 - 252
• Main Authors: Hutcherson, J.A., Bagaitkar, J., Nagano, K., Yoshimura, F., Wang, H., Scott, D.A.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.06.2015
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - immunology; Cytokines - immunology; Gingiva - immunology; Humans; inflammation; Lipopolysaccharides - immunology; monocyte; Monocytes - immunology; NF-kappa B - immunology; periodontitis; Periodontitis - immunology; Phosphorylation; Porphyromonas gingivalis; Porphyromonas gingivalis - genetics; signal transducer and activator of transcription 4; Signal Transduction - immunology; STAT4 Transcription Factor - agonists; Toll-like receptor; Toll-Like Receptor 2 - agonists; Toll-Like Receptor 4 - agonists; Porphyromonas gingivalis; monocyte; signal transducer and activator of transcription 4; inflammation; Toll-like receptor; periodontitis

Summary Periodontal diseases are semi‐ubiquitous and caused by chronic, plaque‐induced inflammation. The 55‐kDa immunodominant RagB outer membrane protein of Porphyromonas gingivalis, a keystone periodontal pathogen, has been proposed to facilitate nutrient transport. However, potential interactions...