Autoantibody detection to tumor-associated antigens of P53, IMP1, P16, cyclin B1, P62, C-myc, Survivn, and Koc for the screening of high-risk subjects and early detection of esophageal squamous cell carcinoma

• Published in: Diseases of the esophagus Vol. 27; no. 8; pp. 790 - 797
• Main Authors: Zhou, S. L., Yue, W. B., Fan, Z. M., Du, F., Liu, B. C., Li, B., Han, X. N., Ku, J. W., Zhao, X. K., Zhang, P., Cui, J., Zhou, F. Y., Zhang, L. Q., Fan, X. P., Zhou, Y. F., Zhu, L. L., Liu, H. Y., Wang, L. D.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2014
• Subjects: Adult; Aged; Antigens, Neoplasm - immunology; Antigens, Neoplasm - metabolism; Autoantibodies - blood; autoantibody; Biomarkers, Tumor - immunology; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - metabolism; Cyclin B1 - immunology; Cyclin B1 - metabolism; Cyclin-Dependent Kinase Inhibitor p16; DNA-Binding Proteins - immunology; DNA-Binding Proteins - metabolism; Early Diagnosis; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - immunology; Esophageal Neoplasms - metabolism; Esophageal Squamous Cell Carcinoma; Female; Humans; Inhibitor of Apoptosis Proteins - immunology; Inhibitor of Apoptosis Proteins - metabolism; Male; Middle Aged; Neoplasm Proteins - immunology; Neoplasm Proteins - metabolism; precancerous lesion; RNA-Binding Proteins - immunology; RNA-Binding Proteins - metabolism; Survivin; Transcription Factors - immunology; Transcription Factors - metabolism; Tumor Suppressor Protein p53 - immunology; Tumor Suppressor Protein p53 - metabolism; tumor-associated antigen (TAA); esophageal squamous cell carcinoma; precancerous lesion; autoantibody; tumor-associated antigen (TAA)

Summary The aim of this study was to evaluate the diagnostic values by detecting sera autoantibodies to eight tumor‐associated antigens (TAAs) of P53, IMP1, P16, cyclin B1, P62, C‐myc, Survivn and Koc full‐length recombinant proteins for the screening of high‐risk subjects and early detection of eso...