Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway

• Published in: The EMBO journal Vol. 31; no. 17; pp. 3513 - 3523
• Main Authors: Zhuang, Guanglei, Wu, Xiumin, Jiang, Zhaoshi, Kasman, Ian, Yao, Jenny, Guan, Yinghui, Oeh, Jason, Modrusan, Zora, Bais, Carlos, Sampath, Deepak, Ferrara, Napoleone
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 29.08.2012; Nature Publishing Group UK; Springer Nature B.V; Nature Publishing Group
• Subjects: Angiogenesis; Animals; Cell Line; Cell Line, Tumor; Cell Movement; Cercopithecus aethiops; COS Cells; EMBO24; EMBO36; Endothelial Cells - physiology; endothelium; Growth factors; Humans; JAK-STAT; Janus Kinase 1 - antagonists & inhibitors; Janus Kinase 1 - metabolism; Janus Kinase 2 - antagonists & inhibitors; Janus Kinase 2 - metabolism; Mice; Mice, Inbred BALB C; microRNA; MicroRNAs - biosynthesis; Molecular biology; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - pathology; Protein Kinase Inhibitors - therapeutic use; Ribonucleic acid; RNA; Signal Transduction; STAT1 Transcription Factor - antagonists & inhibitors; STAT1 Transcription Factor - metabolism; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - metabolism; Suppressor of Cytokine Signaling Proteins - metabolism; Tumors; tumour; Up-Regulation; Vascular endothelial growth factor; Xenograft Model Antitumor Assays; JAK‐STAT; endothelium; microRNA; angiogenesis; tumour

Angiogenesis plays a crucial role during tumorigenesis and much progress has been recently made in elucidating the role of VEGF and other growth factors in the regulation of angiogenesis. Recently, microRNAs (miRNAs) have been shown to modulate a variety of physiogical and pathological processes. We...