Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway - Zhuang, Guanglei; Wu, Xiumin; Jiang, Zhaoshi; Kasman, Ian; Yao, Jenny; Guan, Yinghui; Oeh, Jason; Modrusan, Zora; Bais, Carlos; Sampath, Deepak; Ferrara, Napoleone (The EMBO journal, 2012)
Keywords: Angiogenesis; Animals; Cell Line; Cell Line, Tumor; Cell Movement; Cercopithecus aethiops; COS Cells; EMBO24; EMBO36; Endothelial Cells - physiology; endothelium; Growth factors; Humans; JAK-STAT; Janus Kinase 1 - antagonists & inhibitors; Janus Kinase 1 - metabolism; Janus Kinase 2 - antagonists & inhibitors; Janus Kinase 2 - metabolism; Mice; Mice, Inbred BALB C; microRNA; MicroRNAs - biosynthesis; Molecular biology; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - pathology; Protein Kinase Inhibitors - therapeutic use; Ribonucleic acid; RNA; Signal Transduction; STAT1 Transcription Factor - antagonists & inhibitors; STAT1 Transcription Factor - metabolism; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - metabolism; Suppressor of Cytokine Signaling Proteins - metabolism; Tumors; tumour; Up-Regulation; Vascular endothelial growth factor; Xenograft Model Antitumor Assays; JAK‐STAT; endothelium; microRNA; angiogenesis; tumour