Induction of homologous and cross-reactive GII.4-specific blocking antibodies in children after GII.4 New Orleans norovirus infection

• Published in: Journal of medical virology Vol. 87; no. 10; pp. 1656 - 1661
• Main Authors: Blazevic, Vesna, Malm, Maria, Vesikari, Timo
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: Antibodies, Blocking - immunology; Antibodies, Viral - blood; Antigens; blocking antibodies; Blood Group Antigens; Caliciviridae Infections - immunology; Caliciviridae Infections - virology; Children & youth; Cross Reactions; cross-protection; Enzyme-Linked Immunosorbent Assay; Gastroenteritis - immunology; Gastroenteritis - virology; Genotype; Genotype & phenotype; Humans; IgG; immune responses; Immunoglobulin G - blood; Immunoglobulins; Infant; New Orleans; Norovirus; Norovirus - genetics; Norovirus - immunology; Norovirus - pathogenicity; norovirus GII.4; Rotavirus; Rotavirus - genetics; Viral infections; Virology; New Orleans; IgG; blocking antibodies; norovirus GII.4; cross-protection; immune responses

Noroviruses (NoVs) are major causative agents of acute gastroenteritis (AGE) in children worldwide and the most common viral cause of AGE in countries where rotavirus incidence has been eliminated by vaccination. Previous infections with the dominant GII.4 NoV genotype confer only partial protection...