Tigecycline pharmacokinetics, tolerability, safety, and effect on intestinal microflora in healthy Japanese male subjects

• Published in: Journal of clinical pharmacology Vol. 54; no. 5; p. 513
• Main Authors: Yamashita, Noriaki, Matschke, Kyle, Gandhi, Ashesh, Korth-Bradley, Joan
• Format: Journal Article
• Language: English
• Published: England 01.05.2014
• Subjects: Adult; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Asian Continental Ancestry Group; Bacterial Load; Bacteroides - isolation & purification; Double-Blind Method; Enterobacteriaceae - isolation & purification; Enterococcus - isolation & purification; Feces - chemistry; Healthy Volunteers; Humans; Intestines - microbiology; Male; Microbiota - drug effects; Middle Aged; Minocycline - adverse effects; Minocycline - analogs & derivatives; Minocycline - pharmacokinetics; Minocycline - pharmacology; Nausea - chemically induced; Vomiting - chemically induced; Young Adult; pharmacokinetics; healthy subjects; Japanese; tigecycline

Safety, tolerability, and pharmacokinetics of tigecycline in 76 healthy Japanese subjects were determined in three randomized, double-blind, placebo-controlled studies. Subjects in an ascending single-dose study (n = 40) received 25-150 mg intravenously, whereas subjects in two multiple-dose studies...