Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis

• Published in: The EMBO journal Vol. 31; no. 17; pp. 3607 - 3619
• Main Authors: Laarman, Alexander J, Mijnheer, Gerdien, Mootz, Joe M, van Rooijen, Willemien J M, Ruyken, Maartje, Malone, Cheryl L, Heezius, Erik C, Ward, Richard, Milligan, Graeme, van Strijp, Jos A G, de Haas, Carla J C, Horswill, Alexander R, van Kessel, Kok P M, Rooijakkers, Suzan H M
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 29.08.2012; Nature Publishing Group UK; Springer Nature B.V; Nature Publishing Group
• Subjects: Animals; Bacterial Proteins - immunology; Cells, Cultured; Chemotaxis, Leukocyte - immunology; CXCR2; Cysteine Endopeptidases - immunology; EMBO19; EMBO23; Female; HEK293 Cells; Humans; immune evasion; Immune system; Immunology; Mice; Mice, Inbred C57BL; Microbiology; Molecular biology; Neutrophil Activation - immunology; Neutrophil Infiltration - immunology; Neutrophils - immunology; Pathogens; Proteases; Proteinase inhibitors; Proteins; Receptors, Interleukin-8B - antagonists & inhibitors; Receptors, Interleukin-8B - immunology; Staphylococcus aureus; Staphylococcus infections; U937 Cells; immune evasion; CXCR2; proteases

The CXC chemokine receptor 2 (CXCR2) on neutrophils, which recognizes chemokines produced at the site of infection, plays an important role in antimicrobial host defenses such as neutrophil activation and chemotaxis. Staphylococcus aureus is a successful human pathogen secreting a number of proteoly...