Stress-Related Alcohol Consumption in Heavy Drinkers Correlates with Expression of miR-10a, miR-21, and Components of the TAR-RNA-Binding Protein-Associated Complex

• Published in: Alcoholism, clinical and experimental research Vol. 38; no. 11; pp. 2743 - 2753
• Main Authors: Beech, Robert D., Leffert, Janine J., Lin, Aiping, Hong, Kwangik A., Hansen, Julie, Umlauf, Sheila, Mane, Shrikant, Zhao, Hongyu, Sinha, Rajita
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2014
• Subjects: Adult; Alcohol Dependence; Alcohol Drinking - epidemiology; Alcohol Drinking - metabolism; Alcohol Drinking - psychology; Biomarkers - metabolism; Female; Gene Expression; Gene Expression Regulation; Humans; Male; Microarray; microRNA; MicroRNAs - biosynthesis; Photic Stimulation - methods; RNA-Binding Proteins - biosynthesis; Stress, Psychological - epidemiology; Stress, Psychological - metabolism; Stress, Psychological - psychology; Stress-Related Drinking Behavior; TAR-RNA-Binding Protein-Associated Complex; TAR-RNA-Binding Protein-Associated Complex; microRNA; Gene Expression; Alcohol Dependence; Microarray; Stress-Related Drinking Behavior

Background Alterations in stress‐related gene expression may play a role in stress‐related drinking and the risk of alcohol dependence. Methods Microarrays were used to measure changes in gene expression in peripheral blood in nonsmoking, social drinking subjects exposed to 3 types of personalized i...