Pharmacokinetics and pharmacodynamics of intravenous dexmedetomidine in healthy Korean subjects

• Published in: Journal of clinical pharmacy and therapeutics Vol. 37; no. 6; pp. 698 - 703
• Main Authors: Lee, S., Kim, B.-H., Lim, K., Stalker, D., Wisemandle, W., Shin, S.-G., Jang, I.-J., Yu, K.-S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2012; Blackwell; John Wiley & Sons, Inc
• Subjects: Adrenergic alpha-2 Receptor Agonists - administration & dosage; Adrenergic alpha-2 Receptor Agonists - pharmacokinetics; Adrenergic alpha-2 Receptor Agonists - pharmacology; Adult; Area Under Curve; Biological and medical sciences; dexmedetomidine; Dexmedetomidine - administration & dosage; Dexmedetomidine - pharmacokinetics; Dexmedetomidine - pharmacology; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacokinetics; Hypnotics and Sedatives - pharmacology; Infusions, Intravenous; Korean; Male; Medical sciences; Models, Biological; Nonlinear Dynamics; pharmacodynamics; pharmacokinetics; Pharmacology. Drug treatments; population pharmacokinetics; Republic of Korea; Tissue Distribution; Asia; Korea; Republic of Korea; α2-Adrenergic receptor; Human; Population pharmacokinetics; Pharmacokinetic pharmacodynamic relationship; Agonist; Pharmacodynamics; Intravenous administration; Healthy subject; Korean; Biological activity; Dexmedetomidine; pharmacokinetics; α-Adrenergic receptor agonist

Summary What is known and Objective:  Dexmedetomidine is a selective alpha2‐adrenoreceptor agonist used for sedation in critically ill patients. The current study aimed to evaluate the pharmacokinetics (PKs), pharmacodynamics and tolerability of intravenous dexmedetomidine in healthy Korean subjects...