Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells

• Published in: Acta Physiologica Vol. 217; no. 3; pp. 217 - 226
• Main Authors: López-Yoldi, M., Castilla-Madrigal, R., Lostao, M. P., Barber, A., Prieto, J., Martínez, J. A., Bustos, M., Moreno-Aliaga, M. J.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2016; Wiley Subscription Services, Inc
• Subjects: Aminoimidazole Carboxamide - analogs & derivatives; Aminoimidazole Carboxamide - pharmacology; AMPK; Animals; Caco-2 Cells; Cardiotrophin-1; Cytokines - genetics; Cytokines - metabolism; Cytokines - pharmacology; Enzyme Activation; everted intestinal rings; Humans; Hypoglycemic Agents - pharmacology; In Vitro Techniques; Intestinal Absorption - drug effects; MAP Kinase Signaling System - drug effects; Methylglucosides - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Ribonucleotides - pharmacology; SGLT-1; Sodium-Glucose Transporter 1 - biosynthesis; Sodium-Glucose Transporter 1 - genetics; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - metabolism; sugar uptake; Sugars - metabolism; Tyrphostins - pharmacology; AMPK; Cardiotrophin-1; everted intestinal rings; Caco-2 cells; SGLT-1; sugar uptake

Aim Cardiotrophin‐1 (CT‐1) is a member of the IL‐6 family of cytokines with a key role in glucose and lipid metabolism. In the current investigation, we examined the in vivo and in vitro effects of CT‐1 treatment on intestinal sugar absorption in different experimental models. Methods rCT‐1 effects...