Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

• Published in: Annals of neurology Vol. 78; no. 1; pp. 39 - 53
• Main Authors: Larochelle, Catherine, Lécuyer, Marc-André, Alvarez, Jorge Ivan, Charabati, Marc, Saint-Laurent, Olivia, Ghannam, Soufiane, Kebir, Hania, Flanagan, Ken, Yednock, Ted, Duquette, Pierre, Arbour, Nathalie, Prat, Alexandre
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.07.2015; Wiley Subscription Services, Inc
• Subjects: Animals; Blood-Brain Barrier - immunology; Blood-Brain Barrier - metabolism; Case-Control Studies; CD146 Antigen - metabolism; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell adhesion & migration; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - metabolism; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Humans; In Vitro Techniques; Inflammation; Interferon-gamma - immunology; Interleukin-17 - immunology; Lymphocytes; Melanoma; Mice; Mice, Transgenic; Multiple Sclerosis, Relapsing-Remitting - immunology; Multiple Sclerosis, Relapsing-Remitting - metabolism; Nervous system; Oligodendroglia; Tumor Necrosis Factor-alpha - immunology

Objective Although Tc17 lymphocytes are enriched in the central nervous system (CNS) of multiple sclerosis (MS) subjects and of experimental autoimmune encephalomyelitis (EAE) animals, limited information is available about their recruitment into the CNS and their role in neuroinflammation. Identifi...