Aberrant astrocytes impair vascular reactivity in Huntington disease

• Published in: Annals of neurology Vol. 78; no. 2; pp. 178 - 192
• Main Authors: Hsiao, Han-Yun, Chen, Yu-Chen, Huang, Chien-Hsiang, Chen, Chiao-Chi, Hsu, Yi-Hua, Chen, Hui-Mei, Chiu, Feng-Lan, Kuo, Hung-Chih, Chang, Chen, Chern, Yijuang
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.08.2015; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Animals; Astrocytes - metabolism; Astrocytes - pathology; Blood Vessels - metabolism; Blood Vessels - pathology; Blood Vessels - physiopathology; Brain; Brain - blood supply; Brain - metabolism; Brain - pathology; Cells, Cultured; Female; Humans; Huntingtin Protein; Huntington Disease - metabolism; Huntington Disease - pathology; Huntington Disease - physiopathology; Induced Pluripotent Stem Cells - metabolism; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins - metabolism; Neurons - metabolism; NMR; Nuclear magnetic resonance; Nuclear Proteins - metabolism; Pericytes - pathology; Rodents; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism

Objective Huntington disease (HD) is an inherited neurodegenerative disease caused by the mutant huntingtin gene (mHTT), which harbors expanded CAG repeats. We previously reported that the brain vessel density is higher in mice and patients with HD than in controls. The present study determines whet...