Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation

• Published in: The EMBO journal Vol. 30; no. 8; pp. 1433 - 1443
• Main Authors: Tanneberger, Kristina, Pfister, Astrid S, Brauburger, Katharina, Schneikert, Jean, Hadjihannas, Michel V, Kriz, Vitezslav, Schulte, Gunnar, Bryja, Vitezslav, Behrens, Jürgen
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 20.04.2011; Nature Publishing Group UK; Springer Nature B.V; Nature Publishing Group
• Subjects: 5)P2; Adaptor Proteins, Signal Transducing; Amer1; beta Catenin - genetics; beta Catenin - metabolism; Biodegradation; Blotting, Western; Cell Membrane - metabolism; Cells, Cultured; EMBO37; Embryonic growth stage; Fluorescent Antibody Technique; Glycogen Synthase Kinase 3 - genetics; Glycogen Synthase Kinase 3 - metabolism; Humans; Kidney - cytology; Kidney - metabolism; LDL-Receptor Related Proteins - genetics; LDL-Receptor Related Proteins - metabolism; Low Density Lipoprotein Receptor-Related Protein-6; LRP6; Membrane Proteins - genetics; Membrane Proteins - metabolism; Membranes; Phosphatidylinositol 4,5-Diphosphate - metabolism; Phosphorylation; PtdIns; PtdIns(4,5)P2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Signal Transduction; Translocation; Tumor Suppressor Proteins; Wnt; Wnt Proteins - genetics; Wnt Proteins - metabolism; WTX; WTX; PtdIns(4,5)P; Wnt; Amer1; LRP6

Phosphorylation of the Wnt receptor low‐density lipoprotein receptor‐related protein 6 (LRP6) by glycogen synthase kinase 3β (GSK3β) and casein kinase 1γ (CK1γ) is a key step in Wnt/β‐catenin signalling, which requires Wnt‐induced formation of phosphatidylinositol 4,5‐bisphosphate (PtdIns(4,5)P 2 )....