Serotonin inhibits synaptic glutamate currents in rat nucleus accumbens neurons via presynaptic 5-HT1B receptors

• Published in: The European journal of neuroscience Vol. 10; no. 7; pp. 2371 - 2379
• Main Authors: Muramatsu, Masatoshi, Lapiz, Maria Danet S., Tanaka, Eiichiro, Grenhoff, Johan
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.1998
• Subjects: Animals; brain slice; citalopram; cocaine; Electric Conductivity; Glutamic Acid - physiology; In Vitro Techniques; Male; Medicin och hälsovetenskap; Neurons - physiology; Nucleus Accumbens - cytology; Nucleus Accumbens - physiology; patch clamp; Patch-Clamp Techniques; Presynaptic Terminals - metabolism; Rats; Rats, Sprague-Dawley; Receptors, Serotonin - physiology; Serotonin - pharmacology; Synapses - physiology; whole-cell recording

Neurons in the nucleus accumbens septi in brain slices from adult male rats were studied with patch clamp recording in the whole‐cell conformation. Cells filled with Lucifer Yellow were identified as medium spiny neurons. Electrical stimulation close to the recorded cell evoked excitatory and inhibi...