Melatonin treatment following stroke induction modulates l-arginine metabolism

• Published in: Journal of pineal research Vol. 51; no. 3; pp. 313 - 323
• Main Authors: Nair, Shiva M., Rahman, Rosanna M. A., Clarkson, Andrew N., Sutherland, Brad A., Taurin, Sebastien, Sammut, Ivan A., Appleton, Ian
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011
• Subjects: Animals; arginase; Arginine - metabolism; Blotting, Western; Cell Line, Tumor; Disease Models, Animal; Humans; ischemic stroke; Male; Melatonin; Melatonin - therapeutic use; Middle Cerebral Artery - pathology; middle cerebral artery occlusion; nitric oxide synthase; Nitric Oxide Synthase - metabolism; Prostaglandin-Endoperoxide Synthases - metabolism; Rats; Rats, Sprague-Dawley; Stroke - drug therapy; Stroke - metabolism

:  The efficacy of melatonin treatment in experimental stroke has been established. Some of the neuroprotective properties have been attributed to its anti‐oxidant and anti‐inflammatory effects. Nitric oxide synthases (NOS) and cyclooxygenases (COX) are considered to have a significant role in the i...