The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions

The human c-Ha-ras2 gene, one of two known members of the Harvey ras family, is reportedly located on the I-chromosome and has lost introns (1, 2). There has heretofore been no information on its precise gene structure and oncogenic potential. We have determined the nucleotide sequence of the c-Ha-r...

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Published inNucleic acids research Vol. 12; no. 4; pp. 1821 - 1828
Main Authors Miyoshi, Jun, Kagimoto, Masaaki, Soeda, Ei-ichi, Sakaki, Yoshiyuki
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 24.02.1984
Subjects
Base Composition
Base Sequence
Biological and medical sciences
Cell Transformation, Neoplastic
Cloning, Molecular
DNA Transposable Elements
Female
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genes. Genome
Harvey murine sarcoma virus - genetics
Humans
Molecular and cellular biology
Molecular genetics
Mutation
Oncogenes
Sarcoma Viruses, Murine - genetics
X Chromosome - physiology
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Summary:The human c-Ha-ras2 gene, one of two known members of the Harvey ras family, is reportedly located on the I-chromosome and has lost introns (1, 2). There has heretofore been no information on its precise gene structure and oncogenic potential. We have determined the nucleotide sequence of the c-Ha-ras2 and demonstrate that it is a processed pseudogene surrounded by several direct repeats and contains numerous base substitutions as well as a notable mutation (AGT at codon 12 of the p21 protein) responsible for oncogenic conversion of the known ras genes (3–8).
Bibliography:ArticleID:12.4.1821
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ISSN:0305-1048
1362-4962
DOI:10.1093/nar/12.4.1821