A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin
Introduction Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription. Aim of the study To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tre...
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| Published in | Journal of cosmetic dermatology Vol. 14; no. 1; pp. 40 - 46 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.03.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1473-2130 1473-2165 1473-2165 |
| DOI | 10.1111/jocd.12131 |
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| Abstract | Introduction
Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription.
Aim of the study
To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin.
Material/Methods
In this randomized, parallel, double‐blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84.
Results
A total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream.
Conclusion
The treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures. |
|---|---|
| AbstractList | Introduction
Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription.
Aim of the study
To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin.
Material/Methods
In this randomized, parallel, double‐blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84.
Results
A total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream.
Conclusion
The treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures. Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription.INTRODUCTIONTopical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription.To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin.AIM OF THE STUDYTo compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin.In this randomized, parallel, double-blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84.MATERIAL/METHODSIn this randomized, parallel, double-blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84.A total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream.RESULTSA total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream.The treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures.CONCLUSIONThe treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures. Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription. To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin. In this randomized, parallel, double-blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84. A total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream. The treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures. |
| Author | Bouloc, Anne Issa, Maria Claudia Vergnanini, Andre Luiz |
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| Keywords | retinol tretinoin LR2412 tetra-hydro-jasmonic acid photoaging |
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| References | Mukherjee S, Date A, Patravale V et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging 2006; 1: 327-48. Gold MH, Kircik LH, Bucay VW et al. Treatment of facial photodamage using a novel retinol formulation. J Drugs Dermatol 2013; 12: 533-40. Glogau R. Aesthetic and anatomic analysis of the aging skin. Philadelphia: WB Saunders; Seminars in cutaneous medicine and surgery; 1996: pp. 134-8. Bazin R, Doublet E. Skin Aging Atlas. Volume 1. Caucasian Type. Paris: Editions Med'Com; 2007: pp. 38-51. Kligman LH, Duo CH, Kligman AM. Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connect Tissue Res 1984; 12: 139-50. Tran C, Michelet JF, Simonetti L et al. In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing. J Eur Acad Dermatol Venereol 2014; 28: 415-23. Bloemen MC, van Gerven MS, van der Wal MB et al. An objective device for measuring surface roughness of skin and scars. J Am Acad Dermatol 2011; 64: 706-15. Nyirady J, Bergfeld W, Ellis C et al. Tretinoin cream 0.02% for the treatment of photoaged facial ski: a review of 2 double-blind clinical studies. Cutis 2001; 68: 135-42. Michelet JF, Olive C, Rieux E et al. The anti-ageing potential of a new jasmonic acid derivative (LR2412): in vitro evaluation using reconstructed epidermis Episkin. Exp Dermatol 2012; 21: 398-400. Bruce S. Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging. J Drugs Dermatol 2008; 7 (2 Suppl): s17-22. Kang S, Fisher GJ, Voorhees JJ. Photoaging and topical tretinoin: therapy, pathogenesis, and prevention. Arch Dermatol 1997; 133: 1280-4. Weiss JS, Ellis CN, Headington JT, Voorhees JJ. Topical tretinoin in the treatment of aging skin. J Am Acad Dermatol 1988; 19: 169-75. Ascher B, Fanchon C, Kanoun-Copy L et al. A skincare containing retinol adenosine and hyaluronic acid optimises the benefits from a type A botulinum toxin injection. J Cosmet Laser Ther 2012; 14: 234-8. Fu JJ, Hillebrand GG, Raleigh P et al. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. Br J Dermatol 2010; 162: 647-54. Kang S, Duell EA, Fisher GJ et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 1995; 105: 549-56. Varani J, Warner RL, Gharaee-Kermani M et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000; 114: 480-6. Fluhr JW, Vienne MP, Lauze C et al. Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions. Dermatology 1999; 199 (Suppl 1): 57-60. Ooe M, Seki T, Miura T, Takada A. Comparative evaluation of wrinkle treatments. Aesthetic Plast Surg 2013; 37: 424-33. François G, Maudet A, McDaniel D et al. Quantification of Facial Pores Using Image Analysis. Cosm Dermatol 2009; 22: 457-63. Ho ET, Trookman NS, Sperber BR et al. A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. J Drugs Dermatol 2012; 11: 64-9. 2009; 22 2013; 37 1988; 19 2000; 114 2013; 12 1984; 12 1997; 133 2011; 64 2008; 7 1996 2007 1995; 105 2010; 162 2006; 1 1999; 199 2014; 28 2012; 14 2001; 68 2012; 11 2012; 21 |
| References_xml | – reference: Kang S, Duell EA, Fisher GJ et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 1995; 105: 549-56. – reference: Fluhr JW, Vienne MP, Lauze C et al. Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions. Dermatology 1999; 199 (Suppl 1): 57-60. – reference: Tran C, Michelet JF, Simonetti L et al. In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing. J Eur Acad Dermatol Venereol 2014; 28: 415-23. – reference: Bruce S. Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging. J Drugs Dermatol 2008; 7 (2 Suppl): s17-22. – reference: Nyirady J, Bergfeld W, Ellis C et al. Tretinoin cream 0.02% for the treatment of photoaged facial ski: a review of 2 double-blind clinical studies. Cutis 2001; 68: 135-42. – reference: Ascher B, Fanchon C, Kanoun-Copy L et al. A skincare containing retinol adenosine and hyaluronic acid optimises the benefits from a type A botulinum toxin injection. J Cosmet Laser Ther 2012; 14: 234-8. – reference: Fu JJ, Hillebrand GG, Raleigh P et al. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. Br J Dermatol 2010; 162: 647-54. – reference: Bloemen MC, van Gerven MS, van der Wal MB et al. An objective device for measuring surface roughness of skin and scars. J Am Acad Dermatol 2011; 64: 706-15. – reference: Weiss JS, Ellis CN, Headington JT, Voorhees JJ. Topical tretinoin in the treatment of aging skin. J Am Acad Dermatol 1988; 19: 169-75. – reference: Michelet JF, Olive C, Rieux E et al. The anti-ageing potential of a new jasmonic acid derivative (LR2412): in vitro evaluation using reconstructed epidermis Episkin. Exp Dermatol 2012; 21: 398-400. – reference: Varani J, Warner RL, Gharaee-Kermani M et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000; 114: 480-6. – reference: Ooe M, Seki T, Miura T, Takada A. Comparative evaluation of wrinkle treatments. Aesthetic Plast Surg 2013; 37: 424-33. – reference: Glogau R. Aesthetic and anatomic analysis of the aging skin. Philadelphia: WB Saunders; Seminars in cutaneous medicine and surgery; 1996: pp. 134-8. – reference: Mukherjee S, Date A, Patravale V et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging 2006; 1: 327-48. – reference: Kang S, Fisher GJ, Voorhees JJ. Photoaging and topical tretinoin: therapy, pathogenesis, and prevention. Arch Dermatol 1997; 133: 1280-4. – reference: Gold MH, Kircik LH, Bucay VW et al. Treatment of facial photodamage using a novel retinol formulation. J Drugs Dermatol 2013; 12: 533-40. – reference: Ho ET, Trookman NS, Sperber BR et al. A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. J Drugs Dermatol 2012; 11: 64-9. – reference: Bazin R, Doublet E. Skin Aging Atlas. Volume 1. Caucasian Type. Paris: Editions Med'Com; 2007: pp. 38-51. – reference: Kligman LH, Duo CH, Kligman AM. Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connect Tissue Res 1984; 12: 139-50. – reference: François G, Maudet A, McDaniel D et al. Quantification of Facial Pores Using Image Analysis. Cosm Dermatol 2009; 22: 457-63. – volume: 12 start-page: 533 year: 2013 end-page: 40 article-title: Treatment of facial photodamage using a novel retinol formulation publication-title: J Drugs Dermatol – volume: 11 start-page: 64 year: 2012 end-page: 9 article-title: A randomized, double‐blind, controlled comparative trial of the anti‐aging properties of non‐prescription tri‐retinol 1.1% vs. prescription tretinoin 0.025% publication-title: J Drugs Dermatol – volume: 114 start-page: 480 year: 2000 end-page: 6 article-title: Vitamin A antagonizes decreased cell growth and elevated collagen‐degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin publication-title: J Invest Dermatol – volume: 28 start-page: 415 year: 2014 end-page: 23 article-title: In vitro and in vivo studies with tetra‐hydro‐jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing publication-title: J Eur Acad Dermatol Venereol – volume: 1 start-page: 327 year: 2006 end-page: 48 article-title: Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety publication-title: Clin Interv Aging – volume: 199 start-page: 57 issue: Suppl 1 year: 1999 end-page: 60 article-title: Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long‐term clinical conditions publication-title: Dermatology – start-page: 38 year: 2007 end-page: 51 – volume: 19 start-page: 169 year: 1988 end-page: 75 article-title: Topical tretinoin in the treatment of aging skin publication-title: J Am Acad Dermatol – volume: 21 start-page: 398 year: 2012 end-page: 400 article-title: The anti‐ageing potential of a new jasmonic acid derivative (LR2412): in vitro evaluation using reconstructed epidermis Episkin publication-title: Exp Dermatol – volume: 64 start-page: 706 year: 2011 end-page: 15 article-title: An objective device for measuring surface roughness of skin and scars publication-title: J Am Acad Dermatol – volume: 12 start-page: 139 year: 1984 end-page: 50 article-title: Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue publication-title: Connect Tissue Res – volume: 133 start-page: 1280 year: 1997 end-page: 4 article-title: Photoaging and topical tretinoin: therapy, pathogenesis, and prevention publication-title: Arch Dermatol – volume: 68 start-page: 135 year: 2001 end-page: 42 article-title: Tretinoin cream 0.02% for the treatment of photoaged facial ski: a review of 2 double‐blind clinical studies publication-title: Cutis – volume: 162 start-page: 647 year: 2010 end-page: 54 article-title: A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen publication-title: Br J Dermatol – volume: 37 start-page: 424 year: 2013 end-page: 33 article-title: Comparative evaluation of wrinkle treatments publication-title: Aesthetic Plast Surg – volume: 22 start-page: 457 year: 2009 end-page: 63 article-title: Quantification of Facial Pores Using Image Analysis publication-title: Cosm Dermatol – volume: 7 start-page: s17 issue: 2 Suppl year: 2008 end-page: 22 article-title: Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging publication-title: J Drugs Dermatol – start-page: 134 year: 1996 end-page: 8 – volume: 105 start-page: 549 year: 1995 end-page: 56 article-title: Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation publication-title: J Invest Dermatol – volume: 14 start-page: 234 year: 2012 end-page: 8 article-title: A skincare containing retinol adenosine and hyaluronic acid optimises the benefits from a type A botulinum toxin injection publication-title: J Cosmet Laser Ther |
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| Snippet | Introduction
Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon... Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription. To... Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon... |
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| SubjectTerms | Aged Cyclopentanes - adverse effects Cyclopentanes - therapeutic use Dermatologic Agents - adverse effects Dermatologic Agents - therapeutic use Double-Blind Method Female Humans Keratolytic Agents - adverse effects Keratolytic Agents - therapeutic use LR2412 Middle Aged Oxylipins - adverse effects Oxylipins - therapeutic use photoaging retinol Self-Assessment Skin Aging - drug effects Skin Cream tetra-hydro-jasmonic acid Treatment Outcome tretinoin Tretinoin - adverse effects Tretinoin - therapeutic use |
| Title | A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin |
| URI | https://api.istex.fr/ark:/67375/WNG-G8PQD568-P/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjocd.12131 https://www.ncbi.nlm.nih.gov/pubmed/25603890 https://www.proquest.com/docview/1660426305 |
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