MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma

• Published in: The Laryngoscope Vol. 125; no. 9; p. E306
• Main Authors: Re, Massimo, Çeka, Artan, Rubini, Corrado, Ferrante, Luigi, Zizzi, Antonio, Gioacchini, Federico M, Tulli, Michele, Spazzafumo, Liana, Sellari-Franceschini, Stefano, Procopio, Antonio D, Olivieri, Fabiola
• Format: Journal Article
• Language: English
• Published: United States 01.09.2015
• Subjects: Aged; Aged, 80 and over; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Italy - epidemiology; Laryngeal Neoplasms - genetics; Laryngeal Neoplasms - mortality; Laryngeal Neoplasms - pathology; Male; MicroRNAs - genetics; Middle Aged; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Prognosis; Real-Time Polymerase Chain Reaction; Retrospective Studies; RNA, Neoplasm - genetics; Italy; recurrence; microRNA; miR-34c-5p; Laryngeal squamous cell carcinoma; prognosis; biomarkers
• ISSN: 1531-4995
• DOI: 10.1002/lary.25475

Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC-related miR-34c-5p with disease-free survival and overall survival. Retrospective cohort study. Expression levels of miR-34c-5p were detected in 90 LSCC formalin-fixed paraffin-embedded tissues by reverse-transcription quantitative polymerase chain reaction. Overall survival and disease-free survival were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using Cox proportional hazard analysis. A downregulation of miR-34c-5p expression significantly correlated with worse disease-free and overall survival. In the multivariate analysis, low miR-34c-5p expression was associated with an increased risk of recurrence. A downregulation of miR-34c-5p in LSCC is independently associated with unfavorable disease-free survival, suggesting that miR-34c-5p might be a promising marker for evaluating the risk of recurrences. NA.