Lack of genetic association of 5-HTR2A 102 T/C and -1438A/G polymorphisms with Tourette syndrome in a family-based association study in a Chinese Han population

• Published in: Asia-Pacific psychiatry Vol. 8; no. 1; pp. 87 - 91
• Main Authors: Xu, Longqiang, Zheng, Lanlan, Ma, Jianhua, Su, Nailun, Liu, Yujun, Ma, Xu, Zhang, Xinhua, Liu, Shiguo
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.03.2016; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Asian Continental Ancestry Group - genetics; Asian Continental Ancestry Group - psychology; Attention Deficit Disorder with Hyperactivity - psychology; Child; Child, Preschool; Confidence intervals; Family; Female; Genes; Genetic Predisposition to Disease; Genotype; Haplotypes; HRR; HTR2A -1438A/G; HTR2A102 T/C; Humans; Male; Obsessive-Compulsive Disorder - psychology; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptor, Serotonin, 5-HT2A - genetics; TDT; Tourette syndrome; Tourette Syndrome - genetics; HTR2A -1438A/G; HRR; Tourette syndrome; TDT; HTR2A102 T/C

Introduction Our purpose is to investigate whether polymorphisms of 102 T/C and ‐1438A/G in 5HTR2A are associated with Tourette syndrome (TS) in Chinese Han population. Methods A total of 178 TS trios were recruited in this study. After the allelic and genotypic distributions of two polymorphisms we...