Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

• Published in: Journal of neuroscience research Vol. 88; no. 3; pp. 469 - 477
• Main Authors: Sultana, Rukhsana, Banks, William A., Butterfield, D. Allan
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.02.2010
• Subjects: Alzheimer's disease; hippocampusl; low density lipoprotein receptor (LRP1); mild cognitive impairment; N-methyl D-aspartate receptor-2A (NR2A); post synaptic density protein 95 (PSD95)

Alzheimer's disease (AD) is the most common form of dementia and is pathologically characterized by senile plaques, neurofibrillary tangles, synaptic disruption and loss, and progressive neuronal deficits. The exact mechanism(s) of AD pathogenesis largely remain unknown. With advances in techno...