Haemoglobin in pelvic fluid rescues Fallopian tube epithelial cells from reactive oxygen species stress and apoptosis

• Published in: The Journal of pathology Vol. 240; no. 4; pp. 484 - 494
• Main Authors: Huang, Hsuan-Shun, Hsu, Che-Fang, Chu, Sung-Chao, Chen, Pao-Chu, Ding, Dah-Ching, Chang, Meng-Ya, Chu, Tang-Yuan
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2016; Wiley Subscription Services, Inc
• Subjects: Animals; Apoptosis - physiology; Ascitic Fluid - metabolism; Cell Death - physiology; Cells, Cultured; DNA Breaks, Double-Stranded; DNA double-strand break; Epithelial Cells - cytology; Fallopian tube; Fallopian Tubes - cytology; Female; follicular fluid; haemoglobin; Hemoglobins - analysis; Hemoglobins - physiology; high-grade serous carcinoma; Humans; Menstruation - physiology; Mice, Knockout; NADPH Oxidases - physiology; Ovulation - physiology; Oxidative Stress - physiology; Reactive Oxygen Species - analysis; Reactive Oxygen Species - metabolism; high-grade serous carcinoma; haemoglobin; Fallopian tube; DNA double-strand break; follicular fluid

Fallopian tube fimbrial epithelium is considered to be the major site of origin of ovarian high‐grade serous carcinoma, with p53 loss being the earliest and universal change. We previously reported that reactive oxygen species (ROS) in the ovulatory follicular fluids (FFs) are mutagenic and cytotoxi...