Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early alzheimer's disease

• Published in: Human brain mapping Vol. 35; no. 7; pp. 3132 - 3142
• Main Authors: Chiu, Ming-Jang, Chen, Ya-Fang, Chen, Ta-Fu, Yang, Shieh-Yueh, Yang, Fan-Pei Gloria, Tseng, Tien-Wen, Chieh, Jen-Jie, Chen, Jia-Chun Rare, Tzen, Kai-Yuan, Hua, Mau-Sun, Horng, Herng-Er
• Format: Journal Article
• Language: English
• Published: New York, NY Blackwell Publishing Ltd 01.07.2014; Wiley-Liss; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - complications; Alzheimer Disease - pathology; Alzheimer's disease; Apolipoproteins E - genetics; Biological and medical sciences; biomarker; Brain - pathology; Cognitive Dysfunction - blood; Cognitive Dysfunction - complications; Cognitive Dysfunction - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; hippocampus; Humans; Imaging, Three-Dimensional; immunomagnetic reduction; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Memory Disorders - etiology; Middle Aged; MRI volumetry; Nanoparticles; Nervous system; Neurology; Neuropsychological Tests; plasma total tau; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Regression Analysis; tau Proteins - blood; voxel-based morphometry; Volumetric analysis; Nervous system diseases; Radiodiagnosis; Alzheimer disease; immunomagnetic reduction; Central nervous system; voxel-based morphometry; Memory function; biomarker; Nuclear magnetic resonance imaging; plasma total tau; Cerebral disorder; Encephalon; Voxel; Central nervous system disease; Degenerative disease; Morphometry; Alzheimer's disease; Hippocampus; MRI volumetry; hippocampus

Neurofibrillary tangles are associated with cognitive dysfunction, and hippocampal atrophy with increased CSF tau markers. However, the plasma tau levels of Alzheimer's disease (AD) have not been well studied. We investigated plasma tau by using an immunomagnetic reduction assay in 20 patients...