No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)

• Published in: Environmental and molecular mutagenesis Vol. 36; no. 4; pp. 292 - 300
• Main Authors: Komulainen, Hannu, Hakulinen, Pasi, Servomaa, Kristina, Makkonen, Kaisa, Vasara, Ritva, Mäki-Paakkanen, Jorma, Kosma, Veli-Matti
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 2000; Wiley-Liss
• Subjects: 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone; Animals; Base Sequence; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; carcinogenicity; Chemical agents; chlorination; DNA Primers; drinking water; Female; furanone; Furans - toxicity; Genes, p53; Genes, ras; Ha-ras gene; Immunohistochemistry; K-ras gene; Liver Neoplasms, Experimental - genetics; Male; Medical sciences; Mutagens - toxicity; Mutation; N-ras gene; p53; p53 gene; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proliferating Cell Nuclear Antigen - metabolism; ras; rat; Rats; Rats, Wistar; Tumors; Water Supply; Drinking water; Chlorination; Rat; Liver; p53 Protein; Rodentia; Furan derivatives; Carcinogenesis; Carcinogen; Vertebrata; Mammalia; C-Onc gene; Tumor; Mutation; Tumor suppressor gene

The frequency of point mutations in p53 (exons 4–7) and in Ki‐ras, Ha‐ras, and N‐ras (exons 1 and 2) and the expression of p53 protein were evaluated in the liver tumors of Wistar rats of a 104‐week carcinogenicity study on 3‐chloro‐4‐(dichloromethyl)‐5‐hydroxy‐2(5H)‐furanone (MX), a chlorine disinf...