Development of a Novel Intestinal and Vascular Access Port (IVAP) Rabbit Model to Study Regiospecific Oral Absorption Pharmacokinetics

• Published in: Comparative medicine Vol. 51; no. 4; pp. 349 - 356
• Main Authors: Kunta, Jeevan R., Perry, Barbara A., Sutyak, John P., Sinko, Patrick J.
• Format: Journal Article
• Language: English
• Published: United States American Association for Laboratory Animal Science 01.08.2001
• Subjects: active transport; Administration, Oral; animal models; Animals; blood supply; Catheterization, Peripheral; Catheterization, Peripheral - veterinary; Catheters, Indwelling; Catheters, Indwelling - veterinary; Coated Materials, Biocompatible; Colon; costs and returns; Dimethylpolysiloxanes; Female; Gastrointestinal Motility; halothane; Heparin; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; isoflurane; laboratory animals; Liver; Liver - blood supply; liver function; metabolism; oral administration; Pharmacokinetics; Polyurethanes; portal vein; Portal Vein - surgery; rabbits; Rabbits - metabolism; Rabbits - surgery; Silicones; small intestine; Specific Pathogen-Free Organisms; surgery; veterinary

Background and Purpose: The limited availability and cost of many drugs prohibits routine use of the previously developed intestinal and vascular access port (IVAP) canine model by our group. A lower animal species model such as the rabbit is suitable for implanting intestinal and vascular access po...