Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function

• Published in: Journal of pineal research Vol. 49; no. 1; pp. 86 - 94
• Main Authors: Xu, Shang-Cheng, He, Min-Di, Zhong, Min, Zhang, Yan-Wen, Wang, Yuan, Yang, Lu, Yang, Ju, Yu, Zheng-Ping, Zhou, Zhou
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2010; Blackwell
• Subjects: Adenosine Triphosphate - metabolism; Animals; Biological and medical sciences; Cell Line, Tumor; Cell Survival - drug effects; Cells, Cultured; DNA, Mitochondrial - drug effects; Electron Transport - drug effects; Flow Cytometry; Fundamental and applied biological sciences. Psychology; melatonin; Melatonin - pharmacology; Membrane Potential, Mitochondrial - drug effects; Mice; Mice, Inbred BALB C; Microscopy, Confocal; mitochondria; Nervous System Diseases - chemically induced; Nervous System Diseases - drug therapy; Nervous System Diseases - metabolism; Nervous System Diseases - pathology; Neurons - drug effects; Neurons - metabolism; neurotoxicity; nickel; Nickel - toxicity; oxidative stress; Oxidative Stress - drug effects; Reactive Oxygen Species - metabolism; Toxicity Tests; Vertebrates: endocrinology; Oxidative stress; Mitochondria; Melatonin; neurotoxicity; Nickel; In vitro; Pineal hormone

:  Nickel is a potential neurotoxic pollutant. Oxidative stress is supposed to be involved in the mechanism underlying nickel‐induced neurotoxicity. Melatonin has efficient protective effects against various oxidative damages in nervous system. The purpose of this study was to investigate whether me...