Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients With and Without Delirium Tremens During Acute Withdrawal
Background: Brain‐derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal‐related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at b...
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| Published in | Alcoholism, clinical and experimental research Vol. 35; no. 1; pp. 126 - 131 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2011
Wiley |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background: Brain‐derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal‐related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at baseline and 1 week after alcohol withdrawal among alcoholic patients with and without DT.
Methods: Sixty‐five inpatients, fulfilling the DSM‐IV criteria of alcohol dependence and admitted for alcohol detoxification, as well as 39 healthy control subjects were enrolled. The alcoholic patients were divided by the appearance of DTs into the DT group (n = 25) and non‐DT group (n = 40). We collected blood samples of the patient groups on the first and seventh days of alcohol withdrawal and measured serum BDNF levels by sandwich enzyme‐linked immunosorbent assay.
Results: Serum BDNF levels differed significantly among the three groups: (i) control group 14.8 ± 4.7 ng/ml; (ii) non‐DT group 12.3 ± 3.3 ng/ml; (iii) DT group 6.2 ± 2.6 ng/ml (p < 0.001). One week after alcohol withdrawal, the BDNF levels increased significantly for both alcoholic groups. While non‐DT group had comparable BDNF levels (13.4 ± 3.5 ng/ml) with controls, the DT group still exhibited lower levels (8.9 ± 4.4 ng/ml).
Conclusions: This study suggests chronic drinking leads to a reduction in BDNF levels, and patients with more deficient BDNF expression are vulnerable to the development of DTs. Additionally, BDNF levels elevated after prompt alcohol detoxification treatment. These findings indicate that BDNF could involve modifying the phenotypes of AWS as well as the pertinent neuroadaptive processes of alcohol dependence. |
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| AbstractList | Background: Brain‐derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal‐related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at baseline and 1 week after alcohol withdrawal among alcoholic patients with and without DT.
Methods: Sixty‐five inpatients, fulfilling the DSM‐IV criteria of alcohol dependence and admitted for alcohol detoxification, as well as 39 healthy control subjects were enrolled. The alcoholic patients were divided by the appearance of DTs into the DT group (n = 25) and non‐DT group (n = 40). We collected blood samples of the patient groups on the first and seventh days of alcohol withdrawal and measured serum BDNF levels by sandwich enzyme‐linked immunosorbent assay.
Results: Serum BDNF levels differed significantly among the three groups: (i) control group 14.8 ± 4.7 ng/ml; (ii) non‐DT group 12.3 ± 3.3 ng/ml; (iii) DT group 6.2 ± 2.6 ng/ml (p < 0.001). One week after alcohol withdrawal, the BDNF levels increased significantly for both alcoholic groups. While non‐DT group had comparable BDNF levels (13.4 ± 3.5 ng/ml) with controls, the DT group still exhibited lower levels (8.9 ± 4.4 ng/ml).
Conclusions: This study suggests chronic drinking leads to a reduction in BDNF levels, and patients with more deficient BDNF expression are vulnerable to the development of DTs. Additionally, BDNF levels elevated after prompt alcohol detoxification treatment. These findings indicate that BDNF could involve modifying the phenotypes of AWS as well as the pertinent neuroadaptive processes of alcohol dependence. Brain-derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal-related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at baseline and 1 week after alcohol withdrawal among alcoholic patients with and without DT.BACKGROUNDBrain-derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal-related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at baseline and 1 week after alcohol withdrawal among alcoholic patients with and without DT.Sixty-five inpatients, fulfilling the DSM-IV criteria of alcohol dependence and admitted for alcohol detoxification, as well as 39 healthy control subjects were enrolled. The alcoholic patients were divided by the appearance of DTs into the DT group (n = 25) and non-DT group (n = 40). We collected blood samples of the patient groups on the first and seventh days of alcohol withdrawal and measured serum BDNF levels by sandwich enzyme-linked immunosorbent assay.METHODSSixty-five inpatients, fulfilling the DSM-IV criteria of alcohol dependence and admitted for alcohol detoxification, as well as 39 healthy control subjects were enrolled. The alcoholic patients were divided by the appearance of DTs into the DT group (n = 25) and non-DT group (n = 40). We collected blood samples of the patient groups on the first and seventh days of alcohol withdrawal and measured serum BDNF levels by sandwich enzyme-linked immunosorbent assay.Serum BDNF levels differed significantly among the three groups: (i) control group 14.8 ± 4.7 ng/ml; (ii) non-DT group 12.3 ± 3.3 ng/ml; (iii) DT group 6.2 ± 2.6 ng/ml (p < 0.001). One week after alcohol withdrawal, the BDNF levels increased significantly for both alcoholic groups. While non-DT group had comparable BDNF levels (13.4 ± 3.5 ng/ml) with controls, the DT group still exhibited lower levels (8.9 ± 4.4 ng/ml).RESULTSSerum BDNF levels differed significantly among the three groups: (i) control group 14.8 ± 4.7 ng/ml; (ii) non-DT group 12.3 ± 3.3 ng/ml; (iii) DT group 6.2 ± 2.6 ng/ml (p < 0.001). One week after alcohol withdrawal, the BDNF levels increased significantly for both alcoholic groups. While non-DT group had comparable BDNF levels (13.4 ± 3.5 ng/ml) with controls, the DT group still exhibited lower levels (8.9 ± 4.4 ng/ml).This study suggests chronic drinking leads to a reduction in BDNF levels, and patients with more deficient BDNF expression are vulnerable to the development of DTs. Additionally, BDNF levels elevated after prompt alcohol detoxification treatment. These findings indicate that BDNF could involve modifying the phenotypes of AWS as well as the pertinent neuroadaptive processes of alcohol dependence.CONCLUSIONSThis study suggests chronic drinking leads to a reduction in BDNF levels, and patients with more deficient BDNF expression are vulnerable to the development of DTs. Additionally, BDNF levels elevated after prompt alcohol detoxification treatment. These findings indicate that BDNF could involve modifying the phenotypes of AWS as well as the pertinent neuroadaptive processes of alcohol dependence. Brain-derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal-related neurotoxicity. Delirium tremens (DT) is the most serious complication of alcohol withdrawal syndrome (AWS). In this study, we explored the differences in serum BDNF levels, measured at baseline and 1 week after alcohol withdrawal among alcoholic patients with and without DT. Sixty-five inpatients, fulfilling the DSM-IV criteria of alcohol dependence and admitted for alcohol detoxification, as well as 39 healthy control subjects were enrolled. The alcoholic patients were divided by the appearance of DTs into the DT group (n = 25) and non-DT group (n = 40). We collected blood samples of the patient groups on the first and seventh days of alcohol withdrawal and measured serum BDNF levels by sandwich enzyme-linked immunosorbent assay. Serum BDNF levels differed significantly among the three groups: (i) control group 14.8 ± 4.7 ng/ml; (ii) non-DT group 12.3 ± 3.3 ng/ml; (iii) DT group 6.2 ± 2.6 ng/ml (p < 0.001). One week after alcohol withdrawal, the BDNF levels increased significantly for both alcoholic groups. While non-DT group had comparable BDNF levels (13.4 ± 3.5 ng/ml) with controls, the DT group still exhibited lower levels (8.9 ± 4.4 ng/ml). This study suggests chronic drinking leads to a reduction in BDNF levels, and patients with more deficient BDNF expression are vulnerable to the development of DTs. Additionally, BDNF levels elevated after prompt alcohol detoxification treatment. These findings indicate that BDNF could involve modifying the phenotypes of AWS as well as the pertinent neuroadaptive processes of alcohol dependence. |
| Author | Huang, Ming-Chyi Liu, Hsing-Cheng Chen, Chiao-Chicy Ho, Chia-Chen Chen, Chun-Hsin Leu, Sy-Jye |
| Author_xml | – sequence: 1 givenname: Ming-Chyi surname: Huang fullname: Huang, Ming-Chyi organization: From the Graduate Institute of Medical Sciences (MCH, SJL), College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (MCH, HCL, CCC, CCH), Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry (MCH, CHC, HCL, CCC), School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (CHC), Taipei Medical University-Wan-Fang Hospital, Taipei, Taiwan; Department of Microbiology and Immunology and Center of Reproductive Medicine and Sciences (SJL), Taipei Medical University Hospital, Taipei, Taiwan – sequence: 2 givenname: Chun-Hsin surname: Chen fullname: Chen, Chun-Hsin organization: From the Graduate Institute of Medical Sciences (MCH, SJL), College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (MCH, HCL, CCC, CCH), Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry (MCH, CHC, HCL, CCC), School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (CHC), Taipei Medical University-Wan-Fang Hospital, Taipei, Taiwan; Department of Microbiology and Immunology and Center of Reproductive Medicine and Sciences (SJL), Taipei Medical University Hospital, Taipei, Taiwan – sequence: 3 givenname: Hsing-Cheng surname: Liu fullname: Liu, Hsing-Cheng organization: From the Graduate Institute of Medical Sciences (MCH, SJL), College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (MCH, HCL, CCC, CCH), Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry (MCH, CHC, HCL, CCC), School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (CHC), Taipei Medical University-Wan-Fang Hospital, Taipei, Taiwan; Department of Microbiology and Immunology and Center of Reproductive Medicine and Sciences (SJL), Taipei Medical University Hospital, Taipei, Taiwan – sequence: 4 givenname: Chiao-Chicy surname: Chen fullname: Chen, Chiao-Chicy organization: From the Graduate Institute of Medical Sciences (MCH, SJL), College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (MCH, HCL, CCC, CCH), Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry (MCH, CHC, HCL, CCC), School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (CHC), Taipei Medical University-Wan-Fang Hospital, Taipei, Taiwan; Department of Microbiology and Immunology and Center of Reproductive Medicine and Sciences (SJL), Taipei Medical University Hospital, Taipei, Taiwan – sequence: 5 givenname: Chia-Chen surname: Ho fullname: Ho, Chia-Chen organization: From the Graduate Institute of Medical Sciences (MCH, SJL), College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (MCH, HCL, CCC, CCH), Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry (MCH, CHC, HCL, CCC), School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (CHC), Taipei Medical University-Wan-Fang Hospital, Taipei, Taiwan; Department of Microbiology and Immunology and Center of Reproductive Medicine and Sciences (SJL), Taipei Medical University Hospital, Taipei, Taiwan – sequence: 6 givenname: Sy-Jye surname: Leu fullname: Leu, Sy-Jye organization: From the Graduate Institute of Medical Sciences (MCH, SJL), College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (MCH, HCL, CCC, CCH), Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry (MCH, CHC, HCL, CCC), School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry (CHC), Taipei Medical University-Wan-Fang Hospital, Taipei, Taiwan; Department of Microbiology and Immunology and Center of Reproductive Medicine and Sciences (SJL), Taipei Medical University Hospital, Taipei, Taiwan |
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| Keywords | Human Biological fluid Brain-Derived Neurotrophic Factor (BDNF) Poison withdrawal Ethanol Alcohol Withdrawal Acute Alcoholism Delirium tremens Alcoholic beverage Dependence Disintoxication Serum Brain derived neurotrophic factor Alcohol Dependence Comparative study |
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| Snippet | Background: Brain‐derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal‐related neurotoxicity. Delirium tremens (DT) is the... Brain-derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal-related neurotoxicity. Delirium tremens (DT) is the most serious... |
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| SubjectTerms | Addictive behaviors Adult Adult and adolescent clinical studies Alcohol Dependence Alcohol Withdrawal Alcohol Withdrawal Delirium - blood Alcoholism Alcoholism - blood Alcoholism and acute alcohol poisoning Anticonvulsants - administration & dosage Biological and medical sciences Brain-Derived Neurotrophic Factor (BDNF) Brain-Derived Neurotrophic Factor - blood Central Nervous System Depressants - adverse effects Delirium Tremens Ethanol - adverse effects Female Humans Liver Function Tests Lorazepam - administration & dosage Male Medical sciences Middle Aged Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Substance Withdrawal Syndrome - blood Time Factors Toxicology Young Adult |
| Title | Differential Patterns of Serum Brain-Derived Neurotrophic Factor Levels in Alcoholic Patients With and Without Delirium Tremens During Acute Withdrawal |
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