Brain-Derived Neurotrophic Factor Serum Levels in Alcohol-Dependent Subjects 6 Months After Alcohol Withdrawal

• Published in: Alcoholism, clinical and experimental research Vol. 35; no. 11; pp. 1966 - 1973
• Main Authors: Costa, Marie-Agnès, Girard, Murielle, Dalmay, François, Malauzat, Dominique
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2011; Wiley
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcohol Dependence; Alcoholism; Alcoholism - blood; Alcoholism - psychology; Alcoholism and acute alcohol poisoning; BDNF; Biological and medical sciences; Biomarkers - blood; Blood Cell Count; Blood Cells; Brain-Derived Neurotrophic Factor - blood; Case-Control Studies; Depression - psychology; Female; Follow-Up Studies; gamma-Glutamyltransferase - blood; Humans; Longitudinal Studies; Male; Medical sciences; Middle Aged; Neuronal Plasticity; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Substance Withdrawal Syndrome - blood; Substance Withdrawal Syndrome - psychology; Toxicology; Withdrawal; Human; Biological fluid; Poison withdrawal; Ethanol; BDNF; Withdrawal; Alcoholism; Alcoholic beverage; Neuron; Neuronal Plasticity; Dependence; Plasticity; Disintoxication; Serum; Brain derived neurotrophic factor; Alcohol Dependence

Background:  Diagnosing alcohol dependence is based on clinical signs and on the measured levels of biological markers of alcohol consumption. However, these markers are neither sufficiently sensitive and nor specific enough to definitively determine alcohol dependence. The neuroadaptive changes ass...