FNDC5 could be regulated by leptin in adipose tissue
Introduction Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascula...
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| Published in | European journal of clinical investigation Vol. 44; no. 10; pp. 918 - 925 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.10.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-2972 1365-2362 1365-2362 |
| DOI | 10.1111/eci.12324 |
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| Abstract | Introduction
Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.
Material and methods
We measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression.
Results
Serum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0·043) and after bariatric surgery (P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist‐to‐hip ratio (WHR) (R2 = 0·201) (Beta = −0·357, P = 0·046). Those morbidly obese subjects with android‐type obesity had lower serum irisin levels than those with gynecoid‐type obesity, both before (P = 0·027) and after bariatric surgery (P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = −0·529, P = 0·005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0·009 and P = 0·037, respectively).
Conclusions
We showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin. |
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| AbstractList | Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.
We measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression.
Serum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0·043) and after bariatric surgery (P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist-to-hip ratio (WHR) (R(2) = 0·201) (Beta = -0·357, P = 0·046). Those morbidly obese subjects with android-type obesity had lower serum irisin levels than those with gynecoid-type obesity, both before (P = 0·027) and after bariatric surgery (P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = -0·529, P = 0·005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0·009 and P = 0·037, respectively).
We showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin. Introduction Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors. Material and methods We measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression. Results Serum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0·043) and after bariatric surgery (P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist‐to‐hip ratio (WHR) (R2 = 0·201) (Beta = −0·357, P = 0·046). Those morbidly obese subjects with android‐type obesity had lower serum irisin levels than those with gynecoid‐type obesity, both before (P = 0·027) and after bariatric surgery (P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = −0·529, P = 0·005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0·009 and P = 0·037, respectively). Conclusions We showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin. Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.INTRODUCTIONIrisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.We measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression.MATERIAL AND METHODSWe measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression.Serum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0·043) and after bariatric surgery (P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist-to-hip ratio (WHR) (R(2) = 0·201) (Beta = -0·357, P = 0·046). Those morbidly obese subjects with android-type obesity had lower serum irisin levels than those with gynecoid-type obesity, both before (P = 0·027) and after bariatric surgery (P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = -0·529, P = 0·005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0·009 and P = 0·037, respectively).RESULTSSerum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0·043) and after bariatric surgery (P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist-to-hip ratio (WHR) (R(2) = 0·201) (Beta = -0·357, P = 0·046). Those morbidly obese subjects with android-type obesity had lower serum irisin levels than those with gynecoid-type obesity, both before (P = 0·027) and after bariatric surgery (P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = -0·529, P = 0·005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0·009 and P = 0·037, respectively).We showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin.CONCLUSIONSWe showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin. |
| Author | Perez-Valero, Vidal Garcia-Escobar, Eva Garcia-Arnes, Juan Rodriguez-Pacheco, Francisca Haro-Mora, Juan J. Martinez-Ferriz, Abelardo Santoyo, Julio S. Gonzalo, Montserrat Moreno-Ruiz, Francisco J. Rodriguez-Cañete, Alberto Garcia-Fuentes, Eduardo Soriguer, Federico Gutierrez-Repiso, Carolina Valdes, Sergio Garcia-Serrano, Sara |
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| Keywords | FNDC5 morbid obesity Adipose tissue PCG1-α waist-to-hip ratio irisin leptin |
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Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise publication-title: Metabolism – volume: 20 start-page: 1559 year: 2010 end-page: 67 article-title: Obesity and insulin resistance‐related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects publication-title: Obes Surg – volume: 15 start-page: 292 year: 2012 end-page: 7 article-title: Modulation of leptin resistance by protein tyrosine phosphatases publication-title: Cell Metab – volume: 63 start-page: 60 year: 2013 end-page: 1 article-title: Irisinemia: a novel concept to coin in clinical medicine? publication-title: Ann Nutr Metab – volume: 39 start-page: 125 year: 2013 end-page: 30 article-title: Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index publication-title: Peptides – volume: 12 start-page: 680 year: 2011 end-page: 7 article-title: Body mass index, waist circumference and waist‐hip ratio: which is the better discriminator of cardiovascular disease mortality risk?: evidence from an individual‐participant meta‐analysis of 82 864 participants from nine cohort studies publication-title: Obes Rev – volume: 5 start-page: 181 year: 2007 end-page: 94 article-title: Diet‐induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons publication-title: Cell Metab – volume: 64 start-page: 16 year: 2010 end-page: 22 article-title: Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk–a review of the literature publication-title: Eur J Clin Nutr – volume: 31 start-page: 2258 year: 2008 end-page: 64 article-title: Improved carbohydrate metabolism after bariatric surgery raises antioxidized LDL antibody levels in morbidly obese patients publication-title: Diabetes Care – volume: 27 start-page: 365 year: 2013 end-page: 9 article-title: Lower circulating irisin is associated with type 2 diabetes mellitus publication-title: J Diabetes Complications |
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| Snippet | Introduction
Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different... Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic... |
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| SubjectTerms | Adipose tissue Adult Down-Regulation Female Fibronectins - metabolism FNDC5 GTP-Binding Protein alpha Subunits - metabolism Humans Intra-Abdominal Fat - chemistry irisin leptin Leptin - physiology Male morbid obesity Obesity, Morbid - blood PCG1-α RNA, Messenger - metabolism Subcutaneous Fat - chemistry Waist-Hip Ratio waist-to-hip ratio |
| Title | FNDC5 could be regulated by leptin in adipose tissue |
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