Elevated Ca2+ influx-inducing activity toward mast cells in pretransfusion sera from patients who developed transfusion-related adverse reactions

• Published in: Transfusion (Philadelphia, Pa.) Vol. 49; no. 8; pp. 1754 - 1761
• Main Authors: Azuma, Hiroshi, Yamaguchi, Miki, Takahashi, Daisuke, Fujihara, Mitsuhiro, Sato, Shinichiro, Kato, Toshiaki, Ikeda, Hisami
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.08.2009; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antigens, CD34; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Bone marrow, stem cells transplantation. Graft versus host reaction; Calcium - metabolism; Child; Child, Preschool; Coculture Techniques; Female; Flow Cytometry; Histamine - blood; Humans; Infant; Male; Mast Cells - metabolism; Medical sciences; Middle Aged; Pertussis Toxin - pharmacology; Transfusion Reaction; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Urticaria - blood; Urticaria - etiology; Human; Mast cell; Transfusion

BACKGROUND: Type I allergic reactions such as urticaria‐like manifestations constitute a large percentage of transfusion‐related adverse events. Along with donor factors, patient factors might be involved in these reactions. Sera from some patients with chronic idiopathic urticaria show histamine‐re...