Differential expression of M-CSF, LIF, and TNF-α genes in normal and malignant rat glial cells: Regulation by lipopolysaccharide and vitamin D

• Published in: Journal of neuroscience research Vol. 46; no. 3; pp. 360 - 366
• Main Authors: Furman, I., Baudet, C., Brachet, P.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.11.1996
• Subjects: Animals; calcitriol; Calcitriol - pharmacology; Cytokines - genetics; Gene Expression Regulation - drug effects; Gene Expression Regulation, Neoplastic - drug effects; glial cells; Glioma - genetics; Growth Inhibitors - genetics; Interleukin-6; Leukemia Inhibitory Factor; Lipopolysaccharides - pharmacology; Lymphokines - genetics; macrophage colony-stimulating factor; Macrophage Colony-Stimulating Factor - genetics; Rats; Reference Values; Tumor Necrosis Factor-alpha - genetics; tumor necrosis factor-α; vitamin D; Vitamin D - pharmacology

The effect of 1,25‐dihydroxyvitamin D3 (1,25‐(OH)2D3) on the expression of macrophage colony‐stimulating factor (M‐CSF), leukemia inhibitory factor (LIF), and tumor necrosis factor‐α (TNF‐α) genes in primary rat astrocytes and C6 glioma cells was examined. The results show that the hormone different...