Significant association between the C(−1019)G functional polymorphism of the HTR1A gene and impulsivity

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 153B; no. 2; pp. 592 - 599
• Main Authors: Benko, Anita, Lazary, Judit, Molnar, Eszter, Gonda, Xenia, Tothfalusi, Laszlo, Pap, Dorottya, Mirnics, Zsuzsanna, Kurimay, Tamas, Chase, Diana, Juhasz, Gabriella, Anderson, Ian M., Deakin, John F.W., Bagdy, Gyorgy
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2010; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Age Factors; Alleles; association; Cognition; Female; genetic; Genetics; Genetics, Behavioral; Genotype; Humans; Impulsive Behavior - genetics; impulsiveness; Male; Neurons - metabolism; Polymorphism, Genetic; Receptor, Serotonin, 5-HT1A - genetics; rs6295; serotonin-1A receptor; Sex Factors

Serotonin‐1A (5‐HT1A) receptors are known to play a role in impulsivity‐related behavior. The C(−1019)G functional polymorphism (rs6295) has been suggested to regulate the 5‐HT1A receptor gene (HTR1A) expression in presynaptic raphe neurons, namely, increased receptor concentration and reduced neuro...