Evaluation of plasma-free endocannabinoids and their congeners in abstinent cocaine addicts seeking outpatient treatment: impact of psychiatric co-morbidity

• Published in: Addiction biology Vol. 18; no. 6; pp. 955 - 969
• Main Authors: Pavón, Francisco Javier, Araos, Pedro, Pastor, Antoni, Calado, Montserrat, Pedraz, María, Campos-Cloute, Rafael, Ruiz, Juan Jesús, Serrano, Antonia, Blanco, Eduardo, Rivera, Patricia, Suárez, Juan, Romero-Cuevas, Miguel, Pujadas, Mitona, Vergara-Moragues, Esperanza, Gornemann, Isolde, Torrens, Marta, de la Torre, Rafael, Rodríguez de Fonseca, Fernando
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2013; John Wiley & Sons, Inc
• Subjects: Abuse; Addiction; Adult; Ambulatory Care; Analysis of Variance; Area Under Curve; Biomarkers - blood; Case-Control Studies; Chromatography, Liquid - methods; cocaine; Cocaine-Related Disorders - blood; Cocaine-Related Disorders - epidemiology; Cocaine-Related Disorders - rehabilitation; Comorbidity; dependence; Diagnosis, Dual (Psychiatry); DSM-IV-TR; endocannabinoid; Endocannabinoids - blood; Endocannabinoids - chemistry; Ethanolamines - blood; Ethanolamines - chemistry; Fatty Acids, Monounsaturated - blood; Female; Glycerides - blood; Glycerides - chemistry; Humans; Interview, Psychological; Logistic Models; Male; Mental Disorders - blood; Mental Disorders - epidemiology; Patient Acceptance of Health Care; psychiatric co-morbidity; ROC Curve; Severity of Illness Index; Tandem Mass Spectrometry - methods; endocannabinoid; dependence; DSM-IV-TR; psychiatric co-morbidity; Abuse; cocaine

Cocaine is associated with serious health problems including psychiatric co‐morbidity. There is a need for the identification of biomarkers for the stratification of cocaine‐addicted subjects. Several studies have evaluated circulating endocannabinoid‐related lipids as biomarkers of inflammatory, me...