Acne vulgaris: an inflammasomopathy of the sebaceous follicle induced by deviated FoxO1/mTORC1 signalling

Linked Article: Agamia et al. Br J Dermatol 2016; 174: 1299–1307.

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Published inBritish journal of dermatology (1951) Vol. 174; no. 6; pp. 1186 - 1188
Main Author Melnik, B.C.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.06.2016
Oxford University Press
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Abstract Linked Article: Agamia et al. Br J Dermatol 2016; 174: 1299–1307.
AbstractList Linked Article: Agamia et al. Br J Dermatol 2016; 174: 1299–1307.
Author Melnik, B.C.
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References Mirdamadi Y, Thielitz A, Wiede A et al. Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro. Mol Cell Endocrinol 2015; 415:32-44.
Melnik BC. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol 2015; 8:371-88.
Monfrecola G, Lembo S, Caiazzo G et al. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin. Exp Dermatol 2016; 25:153-5.
Melnik BC. FoxO1 - the key for the pathogenesis and therapy of acne? J Dtsch Dermatol Ges 2010; 8:105-14.
Melnik B. Dietary intervention in acne: attenuation of increased mTORC1 signaling promoted by Western diet. Dermatoendocrinol 2012; 4:20-32.
Cordain L, Lindeberg S, Hurtado M et al. Acne vulgaris: a disease of Western civilization. Arch Dermatol 2002; 138:1584-90.
Fulton JE Jr, Plewig G, Kligman AM. Effect of chocolate on acne vulgaris. JAMA 1969; 210:2071-4.
Agamia NF, Abdallah DM, Sorour O et al. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet. Br J Dermatol 2016; 174:1299-1307.
Zouboulis CC, Jourdan E, Picardo M. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol 2014; 28:527-32.
Melnik BC, Schmitz G. Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1? Exp Dermatol 2013; 22:502-4.
2002; 138
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  article-title: Insulin and insulin‐like growth factor‐1 can modulate the phosphoinositide‐3‐kinase/Akt/FoxO1 pathway in SZ95 sebocytes
  publication-title: Mol Cell Endocrinol
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  start-page: 153
  year: 2016
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  article-title: Mechanistic target of rapamycin (mTOR) expression is increased in acne patients’ skin
  publication-title: Exp Dermatol
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  start-page: 1299
  year: 2016
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  article-title: Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet
  publication-title: Br J Dermatol
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  article-title: Effect of chocolate on acne vulgaris
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  article-title: Acne vulgaris: a disease of Western civilization
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  article-title: Dietary intervention in acne: attenuation of increased mTORC1 signaling promoted by Western diet
  publication-title: Dermatoendocrinol
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  start-page: 105
  year: 2010
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  article-title: FoxO1 – the key for the pathogenesis and therapy of acne?
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  start-page: 502
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SubjectTerms Acne
Acne Vulgaris
Agamia
FOXO1 protein
Humans
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes
Sebaceous Glands
TOR Serine-Threonine Kinases
Title Acne vulgaris: an inflammasomopathy of the sebaceous follicle induced by deviated FoxO1/mTORC1 signalling
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